| Identification |
|---|
| HMDB Protein ID
| CDBP00260 |
| Secondary Accession Numbers
| Not Available |
| Name
| Bisphosphoglycerate mutase |
| Description
| Not Available |
| Synonyms
|
- 2,3-bisphosphoglycerate mutase, erythrocyte
- 2,3-bisphosphoglycerate synthase
- BPG-dependent PGAM
- BPGM
- 2,3-diphosphoglycerate mutase
- DPGM
|
| Gene Name
| BPGM |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.1) and phosphatase (EC 3.1.3.13) activities.
|
| GO Classification
|
| Biological Process |
| respiratory gaseous exchange |
| erythrocyte development |
| carbohydrate metabolic process |
| glycolysis |
| Function |
| catalytic activity |
| isomerase activity |
| intramolecular transferase activity |
| intramolecular transferase activity, phosphotransferases |
| Molecular Function |
| bisphosphoglycerate 2-phosphatase activity |
| bisphosphoglycerate mutase activity |
| phosphoglycerate mutase activity |
| Process |
| glucose catabolic process |
| glycolysis |
| metabolic process |
| small molecule metabolic process |
| alcohol metabolic process |
| monosaccharide metabolic process |
| hexose metabolic process |
| glucose metabolic process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glycolysis / Gluconeogenesis | Not Available |  | | Glycine, serine and threonine metabolism | Not Available |  | | Glycolysis |    | | | Glycogenosis, Type VII. Tarui disease |    | Not Available | | Fanconi-bickel syndrome |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| 7q33 |
| SNPs
| BPGM |
| Gene Sequence
|
>780 bp
ATGTCCAAGTACAAACTTATTATGTTAAGACATGGAGAGGGTGCTTGGAATAAGGAGAAC
CGTTTTTGTAGCTGGGTGGATCAGAAACTCAACAGCGAAGGAATGGAGGAAGCTCGGAAC
TGTGGGAAGCAACTCAAAGCGTTAAACTTTGAGTTTGATCTTGTATTCACATCTGTCCTT
AATCGGTCCATTCACACAGCCTGGCTGATCCTGGAAGAGCTAGGCCAGGAATGGGTGCCT
GTGGAAAGCTCCTGGCGTCTAAATGAGCGTCACTATGGGGCCTTGATCGGTCTCAACAGG
GAGCAGATGGCTTTGAATCATGGTGAAGAACAAGTGAGGCTCTGGAGAAGAAGCTACAAT
GTAACCCCGCCTCCCATTGAGGAGTCTCATCCTTACTACCAAGAAATCTACAACGACCGG
AGGTATAAAGTATGCGATGTGCCCTTGGATCAACTGCCACGGTCGGAAAGCTTAAAGGAT
GTTCTGGAGAGACTCCTTCCCTATTGGAATGAAAGGATTGCTCCCGAAGTATTACGTGGC
AAAACCATTCTGATATCTGCTCATGGAAATAGCAGTAGGGCACTCCTAAAACACCTGGAA
GGTATCTCAGATGAAGACATCATCAACATTACTCTTCCTACTGGAGTCCCCATTCTTCTG
GAATTGGATGAAAACCTGCGTGCTGTTGGGCCTCATCAGTTCCTGGGTGACCAAGAGGCG
ATCCAAGCAGCCATTAAGAAAGTAGAAGATCAAGGAAAAGTGAAACAAGCTAAAAAATAG
|
| Protein Properties |
|---|
| Number of Residues
| 259 |
| Molecular Weight
| 30004.98 |
| Theoretical pI
| 6.543 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Bisphosphoglycerate mutase
MSKYKLIMLRHGEGAWNKENRFCSWVDQKLNSEGMEEARNCGKQLKALNFEFDLVFTSVL
NRSIHTAWLILEELGQEWVPVESSWRLNERHYGALIGLNREQMALNHGEEQVRLWRRSYN
VTPPPIEESHPYYQEIYNDRRYKVCDVPLDQLPRSESLKDVLERLLPYWNERIAPEVLRG
KTILISAHGNSSRALLKHLEGISDEDIINITLPTGVPILLELDENLRAVGPHQFLGDQEA
IQAAIKKVEDQGKVKQAKK
|
| External Links |
|---|
| GenBank ID Protein
| 16877598 |
| UniProtKB/Swiss-Prot ID
| P07738 |
| UniProtKB/Swiss-Prot Entry Name
| PMGE_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| BC017050 |
| GeneCard ID
| BPGM |
| GenAtlas ID
| BPGM |
| HGNC ID
| HGNC:1093 |
| References |
|---|
| General References
| Not Available |