| Identification |
|---|
| HMDB Protein ID
| CDBP00257 |
| Secondary Accession Numbers
| Not Available |
| Name
| Methylsterol monooxygenase 1 |
| Description
| Not Available |
| Synonyms
|
- Methylsterol monooxygenase
- SubName: cDNA FLJ50771, highly similar to C-4 methylsterol oxidase (EC 1.14.13.72)
- C-4 methylsterol oxidase
|
| Gene Name
| MSMO1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in iron ion binding |
| Specific Function
| Not Available |
| GO Classification
|
| Biological Process |
| cholesterol biosynthetic process |
| fatty acid metabolic process |
| fatty acid biosynthetic process |
| Cellular Component |
| integral to membrane |
| endoplasmic reticulum membrane |
| plasma membrane |
| Component |
| endoplasmic reticulum |
| organelle |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| transition metal ion binding |
| iron ion binding |
| oxidoreductase activity |
| Molecular Function |
| C-4 methylsterol oxidase activity |
| iron ion binding |
| Process |
| cellular metabolic process |
| organic acid metabolic process |
| oxoacid metabolic process |
| carboxylic acid metabolic process |
| monocarboxylic acid metabolic process |
| fatty acid metabolic process |
| fatty acid biosynthetic process |
| oxidation reduction |
| metabolic process |
|
| Cellular Location
|
- Endoplasmic reticulum membrane
- Multi-pass membrane protein (Probable)
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | zymosterol biosynthesis | Not Available | Not Available | | Steroid Biosynthesis |    |  | | Smith-Lemli-Opitz Syndrome (SLOS) |    | Not Available | | CHILD Syndrome |    | Not Available | | Desmosterolosis |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| 4q32-q34 |
| SNPs
| SC4MOL |
| Gene Sequence
|
>882 bp
ATGGCAACAAATGAAAGTGTCAGCATCTTTAGTTCAGCATCCTTGGCTGTGGAATATGTA
GATTCACTTTTACCTGAGAATCCTCTGCAAGAACCATTTAAAAATGCTTGGAACTATATG
TTGAATAATTATACAAAGTTCCAGATTGCAACATGGGGATCCCTTATAGTTCATGAAGCC
CTTTATTTCTTATTCTGTTTACCTGGATTTTTATTTCAATTTATACCTTATATGAAAAAA
TACAAAATTCAAAAGGATAAGCCAGAGACATGGGAAAACCAATGGAAGTGTTTCAAAGTT
CTTCTCTTTAATCACTTCTGTATCCAGCTGCCTTTGATTTGTGGAACCTATTATTTTACA
GAGTATTTCAATATTCCTTATGATTGGGAAAGAATGCCAAGATGGTATTTTCTTTTGGCA
AGATGCTTTGGTTGTGCAGTCATTGAAGATACTTGGCACTATTTTCTGCATAGACTCTTA
CACCACAAAAGAATATACAAGTATATTCATAAAGTTCATCATGAGTTTCAGGCTCCATTT
GGAATGGAAGCTGAATATGCACATCCTTTGGAGACTCTAATTCTTGGAACTGGATTTTTC
ATTGGAATCGTGCTTTTGTGTGATCATGTAATTCTTCTTTGGGCATGGGTGACCATTCGT
TTATTAGAAACTATTGATGTCCATAGTGGTTATGATATTCCTCTCAACCCTTTAAATCTG
ATCCCTTTCTATGCTGGTTCTCGGCATCATGATTTCCACCACATGAACTTCATTGGAAAC
TATGCTTCAACATTTACATGGTGGGATCGAATTTTTGGAACAGACTCTCAGTATAATGCC
TATAATGAAAAGAGGAAGAAGTTTGAGAAAAAGACTGAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 293 |
| Molecular Weight
| 19470.325 |
| Theoretical pI
| 7.701 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>C-4 methylsterol oxidase
MATNESVSIFSSASLAVEYVDSLLPENPLQEPFKNAWNYMLNNYTKFQIATWGSLIVHEA
LYFLFCLPGFLFQFIPYMKKYKIQKDKPETWENQWKCFKVLLFNHFCIQLPLICGTYYFT
EYFNIPYDWERMPRWYFLLARCFGCAVIEDTWHYFLHRLLHHKRIYKYIHKVHHEFQAPF
GMEAEYAHPLETLILGTGFFIGIVLLCDHVILLWAWVTIRLLETIDVHSGYDIPLNPLNL
IPFYAGSRHHDFHHMNFIGNYASTFTWWDRIFGTDSQYNAYNEKRKKFEKKTE
|
| External Links |
|---|
| GenBank ID Protein
| 62865628 |
| UniProtKB/Swiss-Prot ID
| Q15800 |
| UniProtKB/Swiss-Prot Entry Name
| ERG25_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U60205 |
| GeneCard ID
| SC4MOL |
| GenAtlas ID
| SC4MOL |
| HGNC ID
| HGNC:10545 |
| References |
|---|
| General References
| Not Available |