| Identification |
|---|
| HMDB Protein ID
| CDBP00255 |
| Secondary Accession Numbers
| Not Available |
| Name
| 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase |
| Description
| Not Available |
| Synonyms
|
- Picolinate carboxylase
|
| Gene Name
| ACMSD |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
|
| GO Classification
|
| Biological Process |
| tryptophan catabolic process |
| quinolinate metabolic process |
| Cellular Component |
| cytosol |
| Function |
| catalytic activity |
| Molecular Function |
| metal ion binding |
| aminocarboxymuconate-semialdehyde decarboxylase activity |
| Process |
| metabolic process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | quinolate metabolism | Not Available | Not Available | | Tryptophan Metabolism |    |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| 2q21.3 |
| SNPs
| ACMSD |
| Gene Sequence
|
>1011 bp
ATGAAAATTGACATCCATAGTCATATTCTACCAAAAGAATGGCCAGATCTAAAAAAGAGG
TTTGGCTACGGAGGCTGGGTGCAGCTCCAACACCACAGCAAGGGAGAAGCAAAGTTGTTG
AAAGATGGGAAAGTCTTCAGAGTGGTGCGAGAGAATTGCTGGGATCCAGAAGTTCGTATT
AGAGAAATGGACCAAAAAGGAGTAACAGTGCAAGCCCTTTCCACAGTTCCTGTCATGTTT
AGCTACTGGGCCAAACCTGAGGACACTTTAAACCTGTGCCAGCTTTTAAACAACGACCTT
GCCAGCACCGTTGTGAGCTACCCCAGGAGGTTCGTGGGTCTGGGGACGTTGCCCATGCAG
GCCCCTGAGCTGGCGGTCAAGGAGATGGAGCGCTGTGTGAAAGAGCTGGGCTTTCCCGGG
GTCCAAATTGGCACCCACGTCAACGAGTGGGACCTGAACGCGCAGGAGCTCTTTCCTGTC
TATGCGGCAGCCGAAAGGCTGAAGTGTTCCCTGTTCGTGCATCCCTGGGACATGCAGATG
GATGGACGAATGGCCAAATACTGGCTCCCTTGGCTTGTAGGAATGCCAGCAGAGACCACC
ATAGCCATTTGCTCCATGATCATGGGTGGAGTATTTGAGAAGTTTCCCAAACTGAAAGTG
TGTTTCGCACATGGTGGTGGTGCCTTCCCCTTCACAGTGGGAAGAATCTCCCATGGATTC
AGCATGCGCCCAGATCTGTGTGCCCAGGACAACCCCATGAACCCGAAGAAATACCTTGGT
TCCTTTTACACAGATGCTTTGGTTCATGATCCTCTGTCCCTCAAGCTGTTAACAGATGTC
ATAGGAAAGGATAAAGTCATTTTGGGAACCGATTACCCCTTTCCACTAGGTGAGCTGGAA
CCTGGGAAACTAATAGAGTCCATGGAAGAATTTGATGAAGAAACAAAGAATAAACTCAAA
GCCGGCAATGCCCTGGCATTTTTGGGTCTTGAGAGAAAACAATTTGAATGA
|
| Protein Properties |
|---|
| Number of Residues
| 336 |
| Molecular Weight
| 38035.045 |
| Theoretical pI
| 6.985 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
MKIDIHSHILPKEWPDLKKRFGYGGWVQLQHHSKGEAKLLKDGKVFRVVRENCWDPEVRI
REMDQKGVTVQALSTVPVMFSYWAKPEDTLNLCQLLNNDLASTVVSYPRRFVGLGTLPMQ
APELAVKEMERCVKELGFPGVQIGTHVNEWDLNAQELFPVYAAAERLKCSLFVHPWDMQM
DGRMAKYWLPWLVGMPAETTIAICSMIMGGVFEKFPKLKVCFAHGGGAFPFTVGRISHGF
SMRPDLCAQDNPMNPKKYLGSFYTDALVHDPLSLKLLTDVIGKDKVILGTDYPFPLGELE
PGKLIESMEEFDEETKNKLKAGNALAFLGLERKQFE
|
| External Links |
|---|
| GenBank ID Protein
| 19911227 |
| UniProtKB/Swiss-Prot ID
| Q8TDX5 |
| UniProtKB/Swiss-Prot Entry Name
| ACMSD_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AB071418 |
| GeneCard ID
| ACMSD |
| GenAtlas ID
| ACMSD |
| HGNC ID
| HGNC:19288 |
| References |
|---|
| General References
| Not Available |