Showing Protein Dopamine beta-hydroxylase (CDBP00247)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 7 compounds
Identification
HMDB Protein ID CDBP00247
Secondary Accession Numbers Not Available
Name Dopamine beta-hydroxylase
Description Not Available
Synonyms
  1. Dopamine beta-monooxygenase
  2. Soluble dopamine beta-hydroxylase
Gene Name DBH
Protein Type Enzyme
Biological Properties
General Function Involved in monooxygenase activity
Specific Function Conversion of dopamine to noradrenaline.
GO Classification
Biological Process
positive regulation of vasoconstriction
visual learning
response to iron ion
memory
leukocyte migration
glucose homeostasis
multicellular organismal aging
response to peptide hormone stimulus
behavioral response to ethanol
response to ozone
cellular response to manganese ion
regulation of apoptotic process
cellular response to nicotine
bone development
blood vessel remodeling
cytokine production
dopamine catabolic process
fear response
norepinephrine biosynthetic process
homoiothermy
response to estradiol stimulus
leukocyte mediated immunity
response to copper ion
maternal behavior
locomotory behavior
synaptic transmission
octopamine metabolic process
response to pain
catecholamine biosynthetic process
response to amphetamine
regulation of cell proliferation
sensory perception of taste
cellular nitrogen compound metabolic process
social behavior
Cellular Component
terminal button
chromaffin granule
chromaffin granule lumen
chromaffin granule membrane
varicosity
extracellular region
neuronal cell body
transport vesicle membrane
membrane
integral to membrane
apical part of cell
dendrite
Function
monooxygenase activity
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
ion binding
cation binding
metal ion binding
copper ion binding
binding
dopamine beta-monooxygenase activity
catalytic activity
transition metal ion binding
Molecular Function
copper ion binding
dopamine beta-monooxygenase activity
L-ascorbic acid binding
Process
metabolic process
cellular process
cellular metabolic process
oxidation reduction
cellular amino acid derivative metabolic process
cellular biogenic amine metabolic process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
catecholamine metabolic process
histidine family amino acid metabolic process
histidine metabolic process
histidine catabolic process
Cellular Location
  1. Cytoplasmic vesicle
  2. Cytoplasmic vesicle
  3. Single-pass type II membrane protein
  4. secretory vesicle membrane
  5. secretory vesicle
  6. chromaffin granule membrane
  7. Single- pass type II membrane protein (Potential)
Pathways
Gene Properties
Chromosome Location 9
Locus 9q34
SNPs DBH
Gene Sequence 
>1854 bp
ATGCCCGCCCTCAGTCGCTGGGCCAGCCTGCCCGGCCCCAGCATGCGGGAGGCAGCCTTC
ATGTACAGCACAGCAGTGGCCATCTTCCTGGTCATCCTGGTGGCCGCACTGCAGGGCTCG
GCTCCCCGTGAGAGCCCCCTCCCCTATCACATCCCCCTGGACCCGGAGGGGTCCCTGGAG
CTCTCATGGAATGTCAGCTACACCCAGGAGGCCATCCATTTCCAGCTCCTGGTGCGGAGG
CTCAAGGCTGGCGTCCTGTTTGGGATGTCCGACCGTGGCGAGCTTGAGAACGCAGATCTC
GTGGTGCTCTGGACCGATGGGGACACTGCCTATTTTGCGGACGCCTGGAGTGACCAGAAG
GGGCAGATCCACCTGGATCCCCAGCAGGACTACCAGCTGCTGCAGGTGCAGAGGACCCCA
GAAGGCCTGACCCTGCTTTTCAAGAGGCCCTTTGGCACCTGCGACCCCAAGGATTACCTC
ATTGAAGACGGCACTGTCCACTTGGTCTACGGGATCCTGGAGGAGCCGTTCCGGTCACTG
GAGGCCATCAACGGCTCGGGCCTGCAGATGGGGCTGCAGAGGGTGCAGCTCCTGAAGCCC
AATATCCCCGAACCGGAGTTGCCCTCAGACGCGTGCACCATGGAGGTCCAAGCTCCCAAT
ATCCAGATCCCCAGCCAGGAGACCACGTACTGGTGCTACATTAAGGAGCTTCCAAAGGGC
TTCTCTCGGCACCACATTATCAAGTACGAGCCCATCGTCACCAAGGGCAATGAGGCCCTT
GTCCACCACATGGAAGTCTTCCAGTGCGCCCCCGAGATGGACAGCGTCCCCCACTTCAGC
GGGCCCTGCGACTCCAAGATGAAACCCGACCGCCTCAACTACTGCCGCCACGTGCTGGCC
GCCTGGGCCCTGGGTGCCAAGGCATTTTACTACCCAGAGGAAGCCGGCCTTGCCTTCGGG
GGTCCAGGGTCCTCCAGATATCTCCGCCTGGAAGTTCACTACCACAACCCACTGGTGATA
GAAGGACGAAACGACTCCTCAGGCATCCGCTTGTACTACACAGCCAAGCTGCGGCGCTTC
AACGCGGGGATCATGGAGCTGGGACTGGTGTACACGCCAGTGATGGCCATTCCACCACGG
GAGACCGCCTTCATCCTCACTGGCTACTGCACGGACAAGTGCACCCAGCTGGCACTGCCT
CCCTCCGGGATCCACATCTTCGCCTCTCAGCTCCACACACACCTGACTGGGAGAAAGGTG
GTCACAGTGCTGGTCCGGGACGGCCGGGAGTGGGAGATCGTGAACCAGGACAATCACTAC
AGCCCTCACTTCCAGGAGATCCGCATGTTGAAGAAGGTCGTGTCGGTCCATCCGGGAGAT
GTGCTCATCACCTCCTGCACGTACAACACAGAAGACCGGGAGCTGGCCACAGTGGGGGGC
TTCGGGATCCTGGAGGAGATGTGTGTCAACTACGTGCACTACTACCCCCAGACGCAGCTG
GAGCTCTGCAAGAGCGCTGTGGACGCCGGCTTCCTGCAGAAGTACTTCCACCTCATCAAC
AGGTTCAACAACGAGGATGTCTGCACCTGCCCTCAGGCGTCCGTGTCTCAGCAGTTCACC
TCTGTTCCCTGGAACTCCTTCAACCGCGACGTACTGAAGGCCCTGTACAGCTTCGCGCCC
ATCTCCATGCACTGCAACAAGTCCTCAGCCGTCCGCTTCCAGGGTGAATGGAACCTGCAG
CCCCTGCCCAAGGTCATCTCCACACTGGAAGAGCCCACCCCACAGTGCCCCACCAGCCAG
GGCCGAAGCCCTGCTGGCCCCACCGTTGTCAGCATTGGTGGGGGCAAAGGCTGA
Protein Properties
Number of Residues 617
Molecular Weight 69064.45
Theoretical pI 6.413
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Dopamine beta-hydroxylase
MPALSRWASLPGPSMREAAFMYSTAVAIFLVILVAALQGSAPRESPLPYHIPLDPEGSLE
LSWNVSYTQEAIHFQLLVRRLKAGVLFGMSDRGELENADLVVLWTDGDTAYFADAWSDQK
GQIHLDPQQDYQLLQVQRTPEGLTLLFKRPFGTCDPKDYLIEDGTVHLVYGILEEPFRSL
EAINGSGLQMGLQRVQLLKPNIPEPELPSDACTMEVQAPNIQIPSQETTYWCYIKELPKG
FSRHHIIKYEPIVTKGNEALVHHMEVFQCAPEMDSVPHFSGPCDSKMKPDRLNYCRHVLA
AWALGAKAFYYPEEAGLAFGGPGSSRYLRLEVHYHNPLVIEGRNDSSGIRLYYTAKLRRF
NAGIMELGLVYTPVMAIPPRETAFILTGYCTDKCTQLALPPSGIHIFASQLHTHLTGRKV
VTVLVRDGREWEIVNQDNHYSPHFQEIRMLKKVVSVHPGDVLITSCTYNTEDRELATVGG
FGILEEMCVNYVHYYPQTQLELCKSAVDAGFLQKYFHLINRFNNEDVCTCPQASVSQQFT
SVPWNSFNRDVLKALYSFAPISMHCNKSSAVRFQGEWNLQPLPKVISTLEEPTPQCPTSQ
GRSPAGPTVVSIGGGKG
GenBank ID Protein 123230459
UniProtKB/Swiss-Prot ID P09172
UniProtKB/Swiss-Prot Entry Name DOPO_HUMAN
PDB IDs Not Available
GenBank Gene ID AL365494
GeneCard ID DBH
GenAtlas ID DBH
HGNC ID HGNC:2689
References
General References Not Available