Cannabis Compound Database: Showing Protein 4-aminobutyrate aminotransferase, mitochondrial (CDBP00242)

Identification Biological properties Gene properties Protein properties External links References XML Show 11 compounds

Identification

HMDB Protein ID

CDBP00242

Secondary Accession Numbers

Not Available

Name

4-aminobutyrate aminotransferase, mitochondrial

Description

Not Available

Synonyms

(S)-3-amino-2-methylpropionate transaminase
GABA aminotransferase
GABA transaminase
GABA-AT
GABA-T
Gamma-amino-N-butyrate transaminase
L-AIBAT

Gene Name

ABAT

Protein Type

Enzyme

Biological Properties

General Function

Involved in 4-aminobutyrate transaminase activity

Specific Function

Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.

GO Classification

Biological Process
neurotransmitter catabolic process
neurotransmitter secretion
response to hypoxia
locomotory behavior
response to iron ion
response to drug
response to ethanol
behavioral response to cocaine
copulation
gamma-aminobutyric acid catabolic process
negative regulation of blood pressure
response to nicotine
Cellular Component
mitochondrial matrix
4-aminobutyrate transaminase complex
Function
binding
catalytic activity
transferase activity
transferase activity, transferring nitrogenous groups
cofactor binding
pyridoxal phosphate binding
transaminase activity
4-aminobutyrate transaminase activity
Molecular Function
pyridoxal phosphate binding
(S)-3-amino-2-methylpropionate transaminase activity
4-aminobutyrate transaminase activity
succinate-semialdehyde dehydrogenase binding
Process
metabolic process
cellular metabolic process
cellular amino acid derivative metabolic process
cellular amino acid and derivative metabolic process
gamma-aminobutyric acid metabolic process

Cellular Location

Mitochondrion matrix

Pathways

Name	SMPDB/Pathwhiz	KEGG
Alanine, aspartate and glutamate metabolism	Not Available
Butanoate metabolism	Not Available
GABAergic synapse	Not Available
Aspartate Metabolism
Canavan Disease		Not Available

Gene Properties

Chromosome Location

Locus

16p13.2

SNPs

ABAT

Gene Sequence

>1503 bp
ATGGCCTCCATGTTGCTCGCCCAGCGCCTGGCCTGCAGCTTCCAGCACAGCTACCGCCTG
CTGGTGCCTGGATCCAGACACATTAGTCAAGCTGCAGCCAAAGTCGACGTTGAATTTGAT
TATGATGGGCCTCTGATGAAGACGGAAGTCCCAGGGCCTAGATCTCAGGAGTTAATGAAA
CAGCTGAATATAATTCAGAATGCAGAGGCTGTGCATTTTTTCTGCAATTACGAAGAGAGC
CGAGGCAATTACCTGGTTGATGTGGACGGCAACCGAATGCTGGATCTTTATTCCCAGATC
TCCTCTGTTCCCATAGGTTACAGCCACCCCGCCCTGCTGAAACTCATCCAACAGCCTCAA
AATGCGAGCATGTTTGTCAACAGACCCGCCCTCGGAATCCTGCCTCCGGAGAACTTTGTG
GAGAAGCTCCGGCAGTCCTTGCTCTCGGTGGCTCCCAAAGGGATGTCCCAGCTCATCACC
ATGGCCTGCGGCTCCTGCTCCAATGAAAACGCCTTAAAGACCATCTTCATGTGGTACCGG
AGCAAGGAAAGAGGGCAGAGGGGCTTCTCCCAGGAGGAGCTGGAGACGTGCATGATTAAC
CAGGCCCCTGGCTGCCCCGACTACAGCATCCTCTCCTTCATGGGCGCGTTCCATGGGAGG
ACCATGGGTTGCTTAGCGACCACGCACTCTAAAGCCATTCACAAGATCGACATCCCTTCC
TTTGACTGGCCCATCGCACCGTTCCCACGGCTGAAATACCCTCTGGAAGAGTTTGTGAAA
GAGAACCAACAGGAGGAGGCCCGCTGTCTGGAAGAGGTGGAGGATCTGATTGTGAAATAT
CGGAAAAAGAAGAAGACGGTGGCCGGGATCATCGTGGAGCCCATCCAGTCCGAGGGTGGA
GACAACCACGCATCCGATGACTTCTTTCGGAAGCTGAGAGACATCGCCAGGAAGCATGGC
TGCGCCTTCTTGGTGGACGAGGTACAGACCGGAGGAGGCTGCACGGGCAAGTTCTGGGCC
CATGAGCACTGGGGCCTGGATGACCCAGCAGACGTGATGACCTTCAGCAAGAAGATGATG
ACTGGGGGCTTCTTCCACAAGGAGGAGTTCAGGCCTAATGCTCCCTACCGGATCTTCAAC
ACCTGGCTGGGGGACCCGTCCAAGAACCTGTTGCTGGCTGAGGTCATCAACATCATCAAG
CGGGAGGACCTGCTAAATAATGCAGCCCATGCCGGGAAGGCCCTGCTCACAGGACTGCTG
GACCTCCAGGCCCGGTACCCCCAGTTCATCAGCAGGGTGAGAGGACGAGGCACCTTTTGC
TCCTTCGATACTCCCGATGATTCCATACGGAATAAGCTCATTTTAATTGCCAGAAACAAA
GGTGTGGTGTTGGGTGGCTGTGGTGACAAATCCATTCGTTTCCGTCCCACGCTGGTCTTC
AGGGATCACCACGCTCACCTGTTCCTCAATATTTTCAGTGACATCTTAGCAGACTTCAAG
TAA

Protein Properties

Number of Residues

500

Molecular Weight

56438.405

Theoretical pI

7.961

Pfam Domain Function

Aminotran_3 (PF00202 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>4-aminobutyrate aminotransferase, mitochondrial
MASMLLAQRLACSFQHSYRLLVPGSRHISQAAAKVDVEFDYDGPLMKTEVPGPRSQELMK
QLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSVPIGYSHPALLKLIQQPQ
NASMFVNRPALGILPPENFVEKLRQSLLSVAPKGMSQLITMACGSCSNENALKTIFMWYR
SKERGQRGFSQEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPS
FDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGG
DNHASDDFFRKLRDIARKHGCAFLVDEVQTGGGCTGKFWAHEHWGLDDPADVMTFSKKMM
TGGFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLNNAAHAGKALLTGLL
DLQARYPQFISRVRGRGTFCSFDTPDDSIRNKLILIARNKGVVLGGCGDKSIRFRPTLVF
RDHHAHLFLNIFSDILADFK

External Links

GenBank ID Protein

158254434

UniProtKB/Swiss-Prot ID

P80404

UniProtKB/Swiss-Prot Entry Name

GABT_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AK290501

GeneCard ID