| Identification |
|---|
| HMDB Protein ID
| CDBP00202 |
| Secondary Accession Numbers
| Not Available |
| Name
| CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase |
| Description
| Not Available |
| Synonyms
|
- Alpha 2,3-ST 3
- Beta-galactoside alpha-2,3-sialyltransferase 3
- Gal beta-1,3(4) GlcNAc alpha-2,3 sialyltransferase
- N-acetyllactosaminide alpha-2,3-sialyltransferase
- ST3Gal III
- ST3GalIII
- ST3N
- Sialyltransferase 6
|
| Gene Name
| ST3GAL3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in sialyltransferase activity |
| Specific Function
| Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- or NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. The highest activity is toward Gal-beta-1,3-GlcNAc and the lowest toward Gal-beta-1,3-GalNAc (By similarity).
|
| GO Classification
|
| Biological Process |
| keratan sulfate biosynthetic process |
| O-glycan processing |
| post-translational protein modification |
| Cellular Component |
| extracellular region |
| Golgi membrane |
| Golgi cisterna membrane |
| integral to Golgi membrane |
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| intrinsic to organelle membrane |
| intrinsic to golgi membrane |
| integral to golgi membrane |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring glycosyl groups |
| sialyltransferase activity |
| Molecular Function |
| beta-galactoside (CMP) alpha-2,3-sialyltransferase activity |
| N-acetyllactosaminide alpha-2,3-sialyltransferase activity |
| Process |
| macromolecule modification |
| protein modification process |
| protein amino acid glycosylation |
| metabolic process |
| macromolecule metabolic process |
|
| Cellular Location
|
- Secreted
- Single-pass type II membrane protein
- Golgi apparatus
- Golgi stack membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | protein glycosylation | Not Available | Not Available | | Other types of O-glycan biosynthesis | Not Available |  | | Glycosaminoglycan biosynthesis - keratan sulfate | Not Available |  | | Glycosphingolipid biosynthesis - lacto and neolacto series | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1p34.1 |
| SNPs
| ST3GAL3 |
| Gene Sequence
|
>1128 bp
ATGGGACTCTTGGTATTTGTGCGCAATCTGCTGCTAGCCCTCTGCCTCTTTCTGGTACTG
GGATTTTTGTATTATTCTGCGTGGAAGCTACACTTACTCCAGTGGGAGGAGGACTCCAAT
TCAGTGGTTCTTTCCTTTGACTCCGCTGGACAAACACTAGGCTCAGAGTATGATCGGTTG
GGCTTCCTCCTGAATCTGGACTCTAAACTGCCTGCTGAATTAGCCACCAAGTACGCAAAC
TTTTCAGAGGGAGCTTGCAAGCCTGGCTATGCTTCAGCCTTGATGACGGCCATCTTCCCC
CGGTTCTCCAAGCCAGCACCCATGTTCCTGGATGACTCCTTTCGCAAGTGGGCTAGAATC
CGGGAGTTCGTGCCGCCTTTTGGGATCAAAGGTCAAGACAATCTGATCAAAGCCATCTTG
TCAGTCACCAAAGAGTACCGCCTGACCCCTGCCTTGGACAGCCTCCGCTGCCGCCGCTGC
ATCATCGTGGGCAATGGAGGCGTTCTTGCCAACAAGTCTCTGGGGTCACGAATTGACGAC
TATGACATTGTGGTGAGACTGAATTCAGCACCAGTGAAAGGCTTTGAGAAGGACGTGGGC
AGCAAAACGACACTGCGCATCACCTACCCCGAGGGCGCCATGCAGCGGCCTGAGCAGTAC
GAGCGCGATTCTCTCTTTGTCCTCGCCGGCTTCAAGTGGCAGGACTTTAAGTGGTTGAAA
TACATCGTCTACAAGGAGAGAGTGAGTGCATCGGATGGCTTCTGGAAATCTGTGGCCACT
CGAGTGCCCAAGGAGCCCCCTGAGATTCGAATCCTCAACCCATATTTCATCCAGGAGGCC
GCCTTCACCCTCATTGGCCTGCCCTTCAACAATGGCCTCATGGGCCGGGGGAACATCCCT
ACCCTTGGCAGTGTGGCAGTGACCATGGCACTACACGGCTGTGACGAGGTGGCAGTCGCA
GGATTTGGCTATGACATGAGCACACCCAACGCACCCCTGCACTACTATGAGACCGTTCGC
ATGGCAGCCATCAAAGAGTCCTGGACGCACAATATCCAGCGAGAGAAAGAGTTTCTGCGG
AAGCTGGTGAAAGCTCGCGTCATCACTGATCTAAGCAGTGGCATCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 375 |
| Molecular Weight
| 38741.57 |
| Theoretical pI
| 8.895 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase
MGLLVFVRNLLLALCLFLVLGFLYYSAWKLHLLQWEEDSNSVVLSFDSAGQTLGSEYDRL
GFLLNLDSKLPAELATKYANFSEGACKPGYASALMTAIFPRFSKPAPMFLDDSFRKWARI
REFVPPFGIKGQDNLIKAILSVTKEYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDD
YDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDFKWLK
YIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIP
TLGSVAVTMALHGCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLR
KLVKARVITDLSSGI
|
| External Links |
|---|
| GenBank ID Protein
| 5454060 |
| UniProtKB/Swiss-Prot ID
| Q11203 |
| UniProtKB/Swiss-Prot Entry Name
| SIAT6_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_006279.2 |
| GeneCard ID
| ST3GAL3 |
| GenAtlas ID
| ST3GAL3 |
| HGNC ID
| HGNC:10866 |
| References |
|---|
| General References
| Not Available |