| Identification |
|---|
| HMDB Protein ID
| CDBP00185 |
| Secondary Accession Numbers
| Not Available |
| Name
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 |
| Description
| Not Available |
| Synonyms
|
- CI-B16.6
- Cell death regulatory protein GRIM-19
- Complex I-B16.6
- GRIM-19
- Gene associated with retinoic and IFN-induced mortality 19 protein
- Gene associated with retinoic and interferon-induced mortality 19 protein
- NADH-ubiquinone oxidoreductase B16.6 subunit
|
| Gene Name
| NDUFA13 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Nucleus
- Single-pass membrane protein
- Mitochondrion inner membrane
- Matrix side
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19p13.2 |
| SNPs
| NDUFA13 |
| Gene Sequence
|
>435 bp
ATGGCGGCGTCAAAGGTGAAGCAGGACATGCCTCCGCCGGGGGGCTATGGGCCCATCGAC
TACAAACGGAACTTGCCGCGTCGAGGACTGTCGGGCTACAGCATGCTGGCCATAGGGATT
GGAACCCTGATCTACGGGCACTGGAGCATAATGAAGTGGAACCGTGAGCGCAGGCGCCTA
CAAATCGAGGACTTCGAGGCTCGCATCGCGCTGTTGCCACTGTTACAGGCAGAAACCGAC
CGGAGGACCTTGCAGATGCTTCGGGAGAACCTGGAGGAGGAGGCCATCATCATGAAGGAC
GTGCCCGACTGGAAGGTGGGGGAGTCTGTGTTCCACACAACCCGCTGGGTGCCCCCCTTG
ATCGGGGAGCTGTACGGGCTGCGCACCACAGAGGAGGCTCTCCATGCCAGCCACGGCTTC
ATGTGGTACACGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 144 |
| Molecular Weight
| 16698.2 |
| Theoretical pI
| 8.84 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
MAASKVKQDMPPPGGYGPIDYKRNLPRRGLSGYSMLAIGIGTLIYGHWSIMKWNRERRRL
QIEDFEARIALLPLLQAETDRRTLQMLRENLEEEAIIMKDVPDWKVGESVFHTTRWVPPL
IGELYGLRTTEEALHASHGFMWYT
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9P0J0 |
| UniProtKB/Swiss-Prot Entry Name
| NDUAD_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF286697 |
| GeneCard ID
| NDUFA13 |
| GenAtlas ID
| NDUFA13 |
| HGNC ID
| HGNC:17194 |
| References |
|---|
| General References
| Not Available |