| Identification |
|---|
| HMDB Protein ID
| CDBP00159 |
| Secondary Accession Numbers
| Not Available |
| Name
| Peroxisomal acyl-coenzyme A oxidase 2 |
| Description
| Not Available |
| Synonyms
|
- 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase
- 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase
- THCA-CoA oxidase
- THCCox
- Trihydroxycoprostanoyl-CoA oxidase
|
| Gene Name
| ACOX2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in acyl-CoA dehydrogenase activity |
| Specific Function
| Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids.
|
| GO Classification
|
| Biological Process |
| bile acid biosynthetic process |
| fatty acid beta-oxidation using acyl-CoA oxidase |
| Cellular Component |
| peroxisomal matrix |
| Component |
| organelle |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| microbody |
| peroxisome |
| Function |
| fad or fadh2 binding |
| oxidoreductase activity, acting on the ch-ch group of donors |
| acyl-coa dehydrogenase activity |
| binding |
| catalytic activity |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| oxidoreductase activity, acting on the ch-ch group of donors, oxygen as acceptor |
| acyl-coa oxidase activity |
| oxidoreductase activity |
| Molecular Function |
| 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity |
| fatty acid binding |
| pristanoyl-CoA oxidase activity |
| acyl-CoA dehydrogenase activity |
| flavin adenine dinucleotide binding |
| Process |
| metabolic process |
| fatty acid catabolic process |
| fatty acid beta-oxidation |
| cellular metabolic process |
| organic acid metabolic process |
| oxoacid metabolic process |
| carboxylic acid metabolic process |
| monocarboxylic acid metabolic process |
| fatty acid metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Peroxisome
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Primary bile acid biosynthesis | Not Available |  | | PPAR signaling pathway | Not Available |  | | Peroxisome | Not Available |  | | Bile Acid Biosynthesis |    | | | Congenital Bile Acid Synthesis Defect Type II |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| 3p14.3 |
| SNPs
| ACOX2 |
| Gene Sequence
|
>2046 bp
ATGGGCAGCCCAGTGCACCGAGTGTCATTGGGGGATACCTGGAGCAGGCAAATGCACCCC
GACATAGAGAGCGAGAGGTATATGCAGTCCTTTGACGTGGAACGGCTCACCAACATCCTT
GATGGAGGTGCCCAGAACACTGCACTCCGCAGGAAAGTTGAGAGCATCATCCACAGTTAC
CCGGAGTTTAGCTGTAAGGACAATTATTTCATGACCCAGAATGAGCGTTATAAGGCTGCC
ATGCGGAGGGCATTCCACATCCGGTTGATAGCTCGGCGCCTGGGTTGGTTAGAAGATGGT
CGTGAATTAGGCTACGCTTACAGAGCCCTTTCTGGAGACGTGGCCTTAAATATACACAGA
GTCTTCGTGAGAGCCCTCAGGAGCCTGGGCTCAGAGGAGCAGATTGCCAAATGGGACCCA
CTCTGCAAAAACATCCAGATCATCGCAACGTATGCACAGACAGAGTTGGGACATGGGACA
TATCTTCAGGGCCTGGAGACTGAAGCCACCTATGACGCAGCCACCCAGGAGTTTGTGATA
CACAGCCCCACGCTGACTGCCACCAAATGGTGGCCTGGAGACTTGGGACGGTCAGCCACC
CATGCCCTGGTCCAGGCCCAGCTGATCTGCTCAGGAGCCAGGCGGGGCATGCACGCTTTT
ATTGTGCCAATCCGGAGTCTTCAGGACCACACCCCACTGCCAGGAATCATCATTGGGGAC
ATCGGACCCAAGATGGACTTTGATCAAACAGACAATGGCTTCCTGCAGCTGAACCATGTG
CGGGTCCCCAGGGAGAACATGCTGAGTCGCTTTGCACAGGTCTTGCCAGATGGCACCTAC
GTCAAACTCGGTACAGCACAGAGCAACTACCTTCCCATGGTGGTGGTGCGGGTGGAGCTG
CTGTCAGGGGAGATCCTCCCTATACTGCAGAAGGCCTGTGTCATCGCCATGCGCTACTCG
GTCATCCGCCGCCAATCCCGGCTCCGGCCCAGTGACCCAGAGGCAAAGGTCCTGGACTAC
CAGACACAACAGCAGAAACTCTTTCCTCAGCTGGCCATCAGTTATGCCTTCCATTTCCTG
GCAGTCAGCCTCTTGGAGTTCTTCCAGCACTCCTACACTGCCATTCTGAACCAAGACTTC
AGCTTCCTGCCTGAGCTCCACGCGCTGAGCACGGGCATGAAGGCCATGATGTCAGAATTC
TGCACCCAGGGAGCTGAGATGTGCCGCAGGGCCTGTGGCGGACATGGCTACTCAAAGCTG
AGTGGCCTGCCATCACTGGTCACCAAATTGTCGGCCTCCTGCACCTACGAGGGTGAGAAC
ACAGTGCTCTACCTGCAGGTGGCCAGGTTCCTGGTGAAGAGCTACCTGCAGACTCAGATG
TCCCCTGGCTCCACGCCACAGAGATCTCTCTCTCCATCTGTCGCATATCTCACCGCACCT
GACCTGGCCAGGTGTCCAGCCCAGAGGGCAGCCGACTTCCTCTGCCCGGAGCTCTACACC
ACGGCCTGGGCACATGTGGCAGTAAGGCTCATAAAGGACTCAGTGCAGCATTTACAGACC
CTGACGCAATCCGGAGCTGACCAGCACGAGGCTTGGAACCAGACCACTGTCATACACCTC
CAGGCTGCTAAGGTGCACTGCTACTATGTCACTGTGAAGGGTTTTACAGAAGCTCTGGAG
AAACTAGAAAATGAACCAGCGATTCAGCAGGTGCTCAAGCGCCTCTGTGACCTCCATGCC
ATACATGGAATCTTGACTAACTCGGGTGACTTTCTCCATGACGCCTTCCTGTCTGGTGCC
CAAGTGGACATGGCAAGAACAGCCTACCTGGACCTGCTCCGCCTGATCCGGAAGGATGCC
ATCCTGTTAACTGATGCTTTTGACTTCACCGATCAGTGTTTAAATTCAGCCCTTGGCTGT
TATGATGGAAACGTCTACGAACGCCTGTTCCAGTGGGCTCAGAAGTCACCAACCAATACT
CAGGAGAACCCTGCCTATGAGGAATATATAAGACCACTTTTACAAAGTTGGAGATCCAAG
CTATGA
|
| Protein Properties |
|---|
| Number of Residues
| 681 |
| Molecular Weight
| 76826.14 |
| Theoretical pI
| 7.559 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Peroxisomal acyl-coenzyme A oxidase 2
MGSPVHRVSLGDTWSRQMHPDIESERYMQSFDVERLTNILDGGAQNTALRRKVESIIHSY
PEFSCKDNYFMTQNERYKAAMRRAFHIRLIARRLGWLEDGRELGYAYRALSGDVALNIHR
VFVRALRSLGSEEQIAKWDPLCKNIQIIATYAQTELGHGTYLQGLETEATYDAATQEFVI
HSPTLTATKWWPGDLGRSATHALVQAQLICSGARRGMHAFIVPIRSLQDHTPLPGIIIGD
IGPKMDFDQTDNGFLQLNHVRVPRENMLSRFAQVLPDGTYVKLGTAQSNYLPMVVVRVEL
LSGEILPILQKACVIAMRYSVIRRQSRLRPSDPEAKVLDYQTQQQKLFPQLAISYAFHFL
AVSLLEFFQHSYTAILNQDFSFLPELHALSTGMKAMMSEFCTQGAEMCRRACGGHGYSKL
SGLPSLVTKLSASCTYEGENTVLYLQVARFLVKSYLQTQMSPGSTPQRSLSPSVAYLTAP
DLARCPAQRAADFLCPELYTTAWAHVAVRLIKDSVQHLQTLTQSGADQHEAWNQTTVIHL
QAAKVHCYYVTVKGFTEALEKLENEPAIQQVLKRLCDLHAIHGILTNSGDFLHDAFLSGA
QVDMARTAYLDLLRLIRKDAILLTDAFDFTDQCLNSALGCYDGNVYERLFQWAQKSPTNT
QENPAYEEYIRPLLQSWRSKL
|
| External Links |
|---|
| GenBank ID Protein
| 1780991 |
| UniProtKB/Swiss-Prot ID
| Q99424 |
| UniProtKB/Swiss-Prot Entry Name
| ACOX2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| X95190 |
| GeneCard ID
| ACOX2 |
| GenAtlas ID
| ACOX2 |
| HGNC ID
| HGNC:120 |
| References |
|---|
| General References
| Not Available |