| Identification |
|---|
| HMDB Protein ID
| CDBP00142 |
| Secondary Accession Numbers
| Not Available |
| Name
| D-aspartate oxidase |
| Description
| Not Available |
| Synonyms
|
- DASOX
- DDO
|
| Gene Name
| DDO |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in D-amino-acid oxidase activity |
| Specific Function
| Selectively catalyzes the oxidative deamination of D-aspartate and its N-methylated derivative, N-methyl D-aspartate.
|
| GO Classification
|
| Biological Process |
| hormone metabolic process |
| aspartate metabolic process |
| D-amino acid catabolic process |
| insemination |
| aspartate catabolic process |
| grooming behavior |
| Cellular Component |
| peroxisome |
| Function |
| binding |
| catalytic activity |
| oxidoreductase activity, acting on the ch-nh2 group of donors |
| oxidoreductase activity, acting on the ch-nh2 group of donors, oxygen as acceptor |
| d-amino-acid oxidase activity |
| oxidoreductase activity |
| Molecular Function |
| D-amino-acid oxidase activity |
| cofactor binding |
| D-aspartate oxidase activity |
| Process |
| metabolic process |
| cellular metabolism |
| electron transport |
| generation of precursor metabolites and energy |
| physiological process |
| metabolism |
| oxidation reduction |
|
| Cellular Location
|
- Cytoplasm
- Peroxisome
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Alanine, aspartate and glutamate metabolism | Not Available |  | | Peroxisome | Not Available |  | | Aspartate Metabolism |    | | | Canavan Disease |    | Not Available | | Hypoacetylaspartia |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| 6q21 |
| SNPs
| DDO |
| Gene Sequence
|
>1110 bp
ATGAGACCAGCCAGGCACTGGGAAACAAGGTTTGGTGCCAGAGATTTTGGTGGCTTCCAA
GACTGCTTTTTCAGAGACAGGCTCATGGACACAGCACGGATTGCAGTTGTCGGGGCAGGT
GTGGTGGGGCTCTCCACGGCTGTGTGCATCTCCAAACTGGTGCCCCGATGCTCCGTTACC
ATCATTTCAGACAAGTTTACTCCAGATACCACCAGTGATGTGGCAGCCGGAATGCTTATT
CCTCACACTTATCCAGATACACCCATTCACACGCAGAAGCAGTGGTTCAGAGAAACCTTT
AATCACCTCTTTGCAATTGCCAATTCTGCAGAAGCTGGAGATGCTGGTGTTCATTTGGTA
TCAGGTTGGCAGATATTTCAGAGCACTCCGACTGAAGAAGTGCCATTCTGGGCTGACGTG
GTTCTGGGATTTCGAAAGATGACTGAGGCTGAGCTGAAGAAATTCCCCCAGTATGTGTTT
GGTCAGGCTTTTACAACCCTGAAATGTGAATGCCCTGCCTACCTCCCGTGGTTGGAGAAA
AGGATAAAGGGAAGTGGAGGCTGGACACTCACTCGGCGAATAGAAGACCTGTGGGAACTT
CATCCGTCCTTTGACATCGTGGTCAACTGTTCAGGCCTTGGAAGCAGACAGCTTGCAGGA
GACTCAAAGATTTTCCCTGTAAGGGGCCAAGTCCTCCAAGTTCAGGCTCCCTGGGTGGAG
CATTTTATCCGAGATGGCAGTGGGCTGACATATATTTATCCTGGTACATCCCATGTAACC
CTAGGTGGAACTAGGCAAAAAGGGGACTGGAATCTGTCCCCGGATGCAGAAAATAGCAGA
GAGATTCTTTCCCGATGCTGTGCTCTGGAGCCCTCCCTCCACGGAGCCTGCAACATCAGG
GAGAAGGTGGGCTTGAGGCCCTACAGGCCAGGCGTGCGACTGCAGACAGAGCTCCTTGCG
CGAGATGGACAGAGGCTGCCTGTAGTCCACCACTATGGCCATGGGAGTGGGGGCATCTCA
GTGCACTGGGGCACTGCTCTGGAGGCCGCCAGGCTGGTGAGCGAGTGTGTCCATGCCCTC
AGGACCCCCATTCCCAAGTCAAACCTGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 341 |
| Molecular Weight
| 40992.53 |
| Theoretical pI
| 8.202 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>D-aspartate oxidase
MDTARIAVVGAGVVGLSTAVCISKLVPRCSVTIISDKFTPDTTSDVAAGMLIPHTYPDTP
IHTQKQWFRETFNHLFAIANSAEAGDAGVHLVSGWQIFQSTPTEEVPFWADVVLGFRKMT
EAELKKFPQYVFGQAFTTLKCECPAYLPWLEKRIKGSGGWTLTRRIEDLWELHPSFDIVV
NCSGLGSRQLAGDSKIFPVRGQVLQVQAPWVEHFIRDGSGLTYIYPGTSHVTLGGTRQKG
DWNLSPDAENSREILSRCCALEPSLHGACNIREKVGLRPYRPGVRLQTELLARDGQRLPV
VHHYGHGSGGISVHWGTALEAARLVSECVHALRTPIPKSNL
|
| External Links |
|---|
| GenBank ID Protein
| 40217815 |
| UniProtKB/Swiss-Prot ID
| Q99489 |
| UniProtKB/Swiss-Prot Entry Name
| OXDD_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_003649 |
| GeneCard ID
| DDO |
| GenAtlas ID
| DDO |
| HGNC ID
| HGNC:2727 |
| References |
|---|
| General References
| Not Available |