| Identification |
|---|
| HMDB Protein ID
| CDBP00135 |
| Secondary Accession Numbers
| Not Available |
| Name
| NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- CI-30kD
- Complex I-30kD
- NADH-ubiquinone oxidoreductase 30 kDa subunit
|
| Gene Name
| NDUFS3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity, acting on NADH or NADPH |
| Specific Function
| Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
|
| GO Classification
|
| Biological Process |
| small molecule metabolic process |
| mitochondrial electron transport, NADH to ubiquinone |
| reactive oxygen species metabolic process |
| induction of apoptosis |
| negative regulation of cell growth |
| Cellular Component |
| mitochondrial respiratory chain complex I |
| Function |
| nadh dehydrogenase activity |
| nadh dehydrogenase (quinone) activity |
| nadh dehydrogenase (ubiquinone) activity |
| oxidoreductase activity |
| oxidoreductase activity, acting on nadh or nadph |
| catalytic activity |
| Molecular Function |
| electron carrier activity |
| NADH dehydrogenase (ubiquinone) activity |
| Process |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Mitochondrion inner membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Oxidative phosphorylation | Not Available |  | | Alzheimer's disease | Not Available |  | | Parkinson's disease | Not Available |  | | Huntington's disease | Not Available |  | | Doxorubicin Metabolism Pathway |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| 11p11.11 |
| SNPs
| NDUFS3 |
| Gene Sequence
|
>795 bp
ATGGCGGCGGCGGCGGTAGCCAGGCTGTGGTGGCGCGGGATCTTGGGGGCCTCGGCGCTG
ACCAGGGGGACTGGGCGACCCTCCGTTCTGTTGCTGCCGGTGAGGCGGGAGAGCGCCGGG
GCCGACACGCGCCCCACTGTCAGACCACGGAATGATGTGGCCCACAAGCAGCTCTCAGCT
TTTGGAGAGTATGTGGCTGAAATCTTGCCCAAGTATGTCCAACAAGTTCAGGTGTCCTGC
TTCAATGAGTTAGAGGTCTGTATCCATCCTGATGGCGTCATCCCAGTGCTGACTTTCCTC
AGGGATCACACCAATGCACAGTTCAAATCTCTGGTTGACTTGACAGCAGTGGACGTCCCA
ACTCGGCAAAACCGTTTTGAGATTGTCTACAACCTGTTGTCTCTGCGCTTCAACTCACGG
ATCCGTGTGAAGACCTACACAGATGAGCTGACGCCCATTGAGTCTGCTGTCTCTGTGTTC
AAGGCAGCCAACTGGTATGAAAGGGAGATCTGGGACATGTTTGGAGTCTTCTTTGCTAAC
CACCCTGATCTAAGAAGGATCCTGACAGATTATGGCTTCGAGGGACATCCTTTCCGGAAA
GACTTTCCTCTATCTGGCTATGTTGAGTTACGTTATGATGATGAAGTGAAGCGGGTGGTG
GCAGAGCCGGTGGAGTTGGCCCAAGAGTTCCGCAAATTTGACCTGAACAGCCCCTGGGAG
GCTTTCCCAGTCTATCGCCAACCCCCGGAGAGTCTCAAGCTTGAAGCCGGAGACAAGAAG
CCTGATGCCAAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 264 |
| Molecular Weight
| 30241.245 |
| Theoretical pI
| 7.497 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
MAAAAVARLWWRGILGASALTRGTGRPSVLLLPVRRESAGADTRPTVRPRNDVAHKQLSA
FGEYVAEILPKYVQQVQVSCFNELEVCIHPDGVIPVLTFLRDHTNAQFKSLVDLTAVDVP
TRQNRFEIVYNLLSLRFNSRIRVKTYTDELTPIESAVSVFKAANWYEREIWDMFGVFFAN
HPDLRRILTDYGFEGHPFRKDFPLSGYVELRYDDEVKRVVAEPVELAQEFRKFDLNSPWE
AFPVYRQPPESLKLEAGDKKPDAK
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| O75489 |
| UniProtKB/Swiss-Prot Entry Name
| NDUS3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF067139 |
| GeneCard ID
| NDUFS3 |
| GenAtlas ID
| NDUFS3 |
| HGNC ID
| HGNC:7710 |
| References |
|---|
| General References
| Not Available |