| Identification |
|---|
| HMDB Protein ID
| CDBP00133 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ribosyldihydronicotinamide dehydrogenase [quinone] |
| Description
| Not Available |
| Synonyms
|
- NRH dehydrogenase [quinone] 2
- NRH:quinone oxidoreductase 2
- QR2
- Quinone reductase 2
|
| Gene Name
| NQO2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in electron carrier activity |
| Specific Function
| The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
|
| GO Classification
|
| Cellular Component |
| cytoplasm |
| nucleus |
| Function |
| binding |
| catalytic activity |
| electron carrier activity |
| coenzyme binding |
| cofactor binding |
| oxidoreductase activity |
| Molecular Function |
| electron carrier activity |
| metal ion binding |
| dihydronicotinamide riboside quinone reductase activity |
| NADPH dehydrogenase (quinone) activity |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| 6p25.2 |
| SNPs
| NQO2 |
| Gene Sequence
|
>696 bp
ATGGCAGGTAAGAAAGTACTCATTGTCTATGCACACCAGGAACCCAAGTCTTTCAACGGA
TCCTTGAAGAATGTGGCTGTAGATGAACTGAGCAGGCAGGGCTGCACCGTCACAGTGTCT
GATTTGTATGCCATGAACTTTGAGCCGAGGGCCACAGACAAAGATATCACTGGTACTCTT
TCTAATCCTGAGGTTTTCAATTATGGAGTGGAAACCCACGAAGCCTACAAGCAAAGGTCT
CTGGCTAGCGACATCACTGATGAGCAGAAAAAGGTTCGGGAGGCTGACCTAGTGATATTT
CAGTTCCCGCTGTACTGGTTCAGCGTGCCGGCCATCCTGAAGGGCTGGATGGATAGGGTG
CTGTGCCAGGGCTTTGCCTTTGACATCCCAGGATTCTACGATTCCGGTTTGCTCCAGGGT
AAACTAGCGCTCCTTTCCGTAACCACGGGAGGCACGGCCGAGATGTACACGAAGACAGGA
GTCAATGGAGATTCTCGATACTTCCTGTGGCCACTCCAGCATGGCACATTACACTTCTGT
GGATTTAAAGTCCTTGCCCCTCAGATCAGCTTTGCTCCTGAAATTGCATCCGAAGAAGAA
AGAAAGGGGATGGTGGCTGCGTGGTCCCAGAGGCTGCAGACCATCTGGAAGGAAGAGCCC
ATCCCCTGCACAGCCCACTGGCACTTCGGGCAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 231 |
| Molecular Weight
| 25918.4 |
| Theoretical pI
| 6.289 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Ribosyldihydronicotinamide dehydrogenase [quinone]
MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTL
SNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRV
LCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFC
GFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P16083 |
| UniProtKB/Swiss-Prot Entry Name
| NQO2_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| J02888 |
| GeneCard ID
| NQO2 |
| GenAtlas ID
| NQO2 |
| HGNC ID
| HGNC:7856 |
| References |
|---|
| General References
| Not Available |