| Identification |
|---|
| HMDB Protein ID
| CDBP00120 |
| Secondary Accession Numbers
| Not Available |
| Name
| NADH-cytochrome b5 reductase 3 |
| Description
| Not Available |
| Synonyms
|
- B5R
- Cytochrome b5 reductase
- Diaphorase-1
- NADH-cytochrome b5 reductase 3 membrane-bound form
- NADH-cytochrome b5 reductase 3 soluble form
|
| Gene Name
| CYB5R3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity |
| Specific Function
| Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.
|
| GO Classification
|
| Biological Process |
| L-ascorbic acid metabolic process |
| cholesterol biosynthetic process |
| blood circulation |
| Cellular Component |
| endoplasmic reticulum membrane |
| endoplasmic reticulum |
| hemoglobin complex |
| mitochondrial outer membrane |
| lipid particle |
| mitochondrial inner membrane |
| Function |
| catalytic activity |
| oxidoreductase activity |
| Molecular Function |
| FAD binding |
| cytochrome-b5 reductase activity |
| Process |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Isoform 2:Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Amino sugar and nucleotide sugar metabolism | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 22 |
| Locus
| 22q13.2 |
| SNPs
| CYB5R3 |
| Gene Sequence
|
>906 bp
ATGGGGGCCCAGCTCAGCACGTTGGGCCATATGGTGCTCTTCCCAGTCTGGTTCCTGTAC
AGTCTGCTCATGAAGCTGTTCCAGCGCTCCACGCCAGCCATCACCCTCGAGAGCCCGGAC
ATCAAGTACCCGCTGCGGCTCATCGACCGGGAGATCATCAGCCATGACACCCGGCGCTTC
CGCTTTGCCCTGCCGTCACCCCAGCACATCCTGGGCCTCCCTGTCGGCCAGCACATCTAC
CTCTCGGCTCGAATTGATGGAAACCTGGTCGTCCGGCCCTATACACCCATCTCCAGCGAT
GATGACAAGGGCTTCGTGGACCTGGTCATCAAGGTTTACTTCAAGGACACCCATCCCAAG
TTTCCCGCTGGAGGGAAGATGTCTCAGTACCTGGAGAGCATGCAGATTGGAGACACCATT
GAGTTCCGGGGCCCCAGTGGGCTGCTGGTCTACCAGGGCAAAGGGAAGTTCGCCATCCGA
CCTGACAAAAAGTCCAACCCTATCATCAGGACAGTGAAGTCTGTGGGCATGATCGCGGGA
GGGACAGGCATCACCCCGATGCTGCAGGTGATCCGCGCCATCATGAAGGACCCTGATGAC
CACACTGTGTGCCACCTGCTCTTTGCCAACCAGACCGAGAAGGACATCCTGCTGCGACCT
GAGCTGGAGGAACTCAGGAACAAACATTCTGCACGCTTCAAGCTCTGGTACACGCTGGAC
AGAGCCCCTGAAGCCTGGGACTACGGCCAGGGCTTCGTGAATGAGGAGATGATCCGGGAC
CACCTTCCACCCCCAGAGGAGGAGCCGCTGGTGCTGATGTGTGGCCCCCCACCCATGATC
CAGTACGCCTGCCTTCCCAACCTGGACCACGTGGGCCACCCCACGGAGCGCTGCTTCGTC
TTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 301 |
| Molecular Weight
| 34234.55 |
| Theoretical pI
| 7.599 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>NADH-cytochrome b5 reductase 3
MGAQLSTLGHMVLFPVWFLYSLLMKLFQRSTPAITLESPDIKYPLRLIDREIISHDTRRF
RFALPSPQHILGLPVGQHIYLSARIDGNLVVRPYTPISSDDDKGFVDLVIKVYFKDTHPK
FPAGGKMSQYLESMQIGDTIEFRGPSGLLVYQGKGKFAIRPDKKSNPIIRTVKSVGMIAG
GTGITPMLQVIRAIMKDPDDHTVCHLLFANQTEKDILLRPELEELRNKHSARFKLWYTLD
RAPEAWDYGQGFVNEEMIRDHLPPPEEEPLVLMCGPPPMIQYACLPNLDHVGHPTERCFV
F
|
| External Links |
|---|
| GenBank ID Protein
| 1695155 |
| UniProtKB/Swiss-Prot ID
| P00387 |
| UniProtKB/Swiss-Prot Entry Name
| NB5R3_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| Y09501 |
| GeneCard ID
| CYB5R3 |
| GenAtlas ID
| CYB5R3 |
| HGNC ID
| HGNC:2873 |
| References |
|---|
| General References
| Not Available |