| Identification |
|---|
| HMDB Protein ID
| CDBP00118 |
| Secondary Accession Numbers
| Not Available |
| Name
| Peroxisomal N(1)-acetyl-spermine/spermidine oxidase |
| Description
| Not Available |
| Synonyms
|
- Polyamine oxidase
|
| Gene Name
| PAOX |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.
|
| GO Classification
|
| Biological Process |
| small molecule metabolic process |
| xenobiotic metabolic process |
| polyamine catabolic process |
| positive regulation of spermidine biosynthetic process |
| putrescine biosynthetic process |
| putrescine catabolic process |
| spermidine catabolic process |
| spermine catabolic process |
| Cellular Component |
| peroxisomal matrix |
| Molecular Function |
| N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity |
| polyamine oxidase activity |
| spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity |
| spermine:oxygen oxidoreductase (spermidine-forming) activity |
| N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity |
| N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity |
|
| Cellular Location
|
- Cytoplasm
- Peroxisome
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | spermine metabolism | Not Available | Not Available | | Peroxisome | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| 10q26.3 |
| SNPs
| PAOX |
| Gene Sequence
|
>1950 bp
ATGGAGTCGACCGGCAGCGTCGGGGAGGCCCCGGGCGGACCCCGGGTGCTGGTGGTGGGC
GGCGGCATCGCGGGGCTGGGCGCGGCGCAGAGGCTCTGCGGCCACTCCGCCTTCCCGCAC
CTACGGGTCCTGGAGGCCACGGCCCGTGCCGGGGGCCGCATCCGCTCGGAGCGCTGCTTC
GGTGGCGTGGTGGAGGTGGGCGCGCACTGGATCCATGGGCCCTCCCGGGGTAACCCCGTC
TTCCAGCTGGCTGCTGAGTACGGGCTGCTGGGGGAGAAGGAGCTGTCCCAGGAGAACCAG
CTGGTGGAGACCGGGGGTCACGTGGGCCTGCCCTCCGTGAGCTACGCCAGCTCCGGGACC
AGCGTGAGCCTCCAGCTGGTGGCGGAGATGGCGACTCTGTTCTACGGCCTGATAGACCAG
ACCCGGGAGTTCCTGCACGCTGCAGAGACCCCGGTGCCCAGCGTCGGGGAGTACCTCAAG
AAGGAGATTGGCCAGCACGTGGCGAGGCTCTGCGGCCACTCCGCCTTCCCACACCTGCGG
GTCCTGGAGGCCACGGCCCGCGCCGGGGGCCGCATCCGCTCGGAGCGCTGCTTCGGTGGC
GTGGTGGAGGTGGGCGCGCACTGGATCCATGGGCCCTCCCGGGGTAACCCCGTCTTCCAG
CTGGCTGCTGAGTACGGGCTGCTGGGGGAGAAGGAGCTGTCCCAGGAGAACCAGCTGGTG
GAGACCGGGGGTCACGTGGGCCTGCCCTCCGTGAGCTACGCCAGCTCCGGAGCCAGCGTG
AGCCTCCAGCTGGTGGCGGAGATGGCGACTCTGTTCTACGGCCTGATAGACCAGACCCGG
GAGTTCCTGCACGCTGCAGAGACCCCGGTGCCCAGCGTCGGGGAGTACCTCAAGAAGGAG
ATTGGCCAGCACGTGGCCGGCTGGACAGAGGATGAGGAGACCAGGAAGCTGAAGCTGGCC
GTCCTGAACTCCTTCTTCAACCTGGAATGCTGTGTGAGCGGCACCCACAGCATGGACCTG
GTGGCCCTGGCACCCTTTGGGGAGTATACCGTGCTGCCGGGGCTGGACTGCACCTTTTCT
AAGGGCTATCAAGGACTCACAAACTGCATGATGGCCGCCCTGCCGGAGGACACTGTAGTT
TTTGAGAAGCCTGTGAAGACCATCCACTGGAACGGGTCCTTCCAGGAGGCAGCCTTTCCC
GGGGAGACCTTTCCAGTGTCGGTAGAGTGTGAGGATGGAGACCGGTTCCCGGCGCACCAT
GTCATCGTCACCGTGCCCTTAGGTTTTCTTAGGGAACATTTGGACACCTTCTTTGACCCT
CCCCTGCCGGCTGAGAAGGCAGAAGCAATCAGGAAGATAGGCTTTGGGACCAACAACAAA
ATCTTCCTGGAGTTTGAGGAGCCCTTCTGGGAGCCAGACTGCCAGCTGATCCAGCTGGTG
TGGGAGGACACGTCGCCCCTGGAGGATGCTGCCCCTGAGCTACAGGACGCCTGGTTCCGG
AAGCTCATTGGCTTTGTGGTCCTGCCTGCCTTTGCGTCTGTCCACGTTCTCTGTGGGTTC
ATTGCCGGACTTGAGTCTGAGTTCATGGAGACTCTGTCGGATGAAGAAGTACTTCTGTGT
CTCACCCAAGTGCTCCGGAGAGTGACAGGAAACCCACGGCTCCCCGCGCCCAAGAGCGTC
CTGCGGTCTCGCTGGCACAGCGCCCCGTACACTAGGGGGTCCTACAGCTACGTGGCCGTG
GGCAGTACTGGGGGCGACCTGGACCTGCTGGCTCAGCCCCTCCCTGCAGACGGCGCCGGC
GCCCAGCTCCAGATCCTGTTTGCGGGGGAAGCCACACATCGCACGTTTTACTCCACGACG
CACGGGGCTCTGCTGTCGGGATGGAGGGAGGCCGACCGCCTCCTCAGTCTGTGGGCCCCG
CAGGTGCAGCAGCCCAGGCCGAGGCTCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 649 |
| Molecular Weight
| 55512.64 |
| Theoretical pI
| 5.233 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Peroxisomal N(1)-acetyl-spermine/spermidine oxidase
MESTGSVGEAPGGPRVLVVGGGIAGLGAAQRLCGHSAFPHLRVLEATARAGGRIRSERCF
GGVVEVGAHWIHGPSRGNPVFQLAAEYGLLGEKELSQENQLVETGGHVGLPSVSYASSGT
SVSLQLVAEMATLFYGLIDQTREFLHAAETPVPSVGEYLKKEIGQHVARLCGHSAFPHLR
VLEATARAGGRIRSERCFGGVVEVGAHWIHGPSRGNPVFQLAAEYGLLGEKELSQENQLV
ETGGHVGLPSVSYASSGASVSLQLVAEMATLFYGLIDQTREFLHAAETPVPSVGEYLKKE
IGQHVAGWTEDEETRKLKLAVLNSFFNLECCVSGTHSMDLVALAPFGEYTVLPGLDCTFS
KGYQGLTNCMMAALPEDTVVFEKPVKTIHWNGSFQEAAFPGETFPVSVECEDGDRFPAHH
VIVTVPLGFLREHLDTFFDPPLPAEKAEAIRKIGFGTNNKIFLEFEEPFWEPDCQLIQLV
WEDTSPLEDAAPELQDAWFRKLIGFVVLPAFASVHVLCGFIAGLESEFMETLSDEEVLLC
LTQVLRRVTGNPRLPAPKSVLRSRWHSAPYTRGSYSYVAVGSTGGDLDLLAQPLPADGAG
AQLQILFAGEATHRTFYSTTHGALLSGWREADRLLSLWAPQVQQPRPRL
|
| External Links |
|---|
| GenBank ID Protein
| 45439842 |
| UniProtKB/Swiss-Prot ID
| Q6QHF9 |
| UniProtKB/Swiss-Prot Entry Name
| PAOX_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY541520 |
| GeneCard ID
| PAOX |
| GenAtlas ID
| PAOX |
| HGNC ID
| HGNC:20837 |
| References |
|---|
| General References
| Not Available |