| Identification |
|---|
| HMDB Protein ID
| CDBP00117 |
| Secondary Accession Numbers
| Not Available |
| Name
| Peroxisomal sarcosine oxidase |
| Description
| Not Available |
| Synonyms
|
- L-pipecolate oxidase
- L-pipecolic acid oxidase
- PSO
|
| Gene Name
| PIPOX |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity |
| Specific Function
| Metabolizes sarcosine, L-pipecolic acid and L-proline.
|
| GO Classification
|
| Biological Process |
| L-lysine catabolic process to acetyl-CoA via L-pipecolate |
| tetrahydrofolate metabolic process |
| Cellular Component |
| peroxisome |
| Function |
| catalytic activity |
| oxidoreductase activity, acting on the ch-nh group of donors |
| oxidoreductase activity, acting on the ch-nh group of donors, oxygen as acceptor |
| sarcosine oxidase activity |
| oxidoreductase activity |
| Molecular Function |
| L-pipecolate oxidase activity |
| sarcosine oxidase activity |
| Process |
| metabolic process |
| cellular aromatic compound metabolic process |
| folic acid and derivative metabolic process |
| tetrahydrofolate metabolic process |
| cellular metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Peroxisome
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glycine, serine and threonine metabolism | Not Available |  | | Peroxisome | Not Available |  | | Lysine Degradation |    |  | | Saccharopinuria/Hyperlysinemia II |    | Not Available | | Hyperlysinemia I, Familial |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| 17q11.2 |
| SNPs
| PIPOX |
| Gene Sequence
|
>1173 bp
ATGGCGGCTCAGAAAGATCTCTGGGACGCCATTGTGATTGGGGCGGGGATCCAGGGCTGC
TTCACTGCATACCACCTCGCCAAACACAGGAAGAGGATCCTCCTGCTGGAGCAGTTCTTT
CTACCACACTCCCGAGGAAGCTCCCATGGACAAAGCCGGATAATCCGAAAGGCGTACCTG
GAAGACTTTTACACCCGGATGATGCATGAGTGCTATCAGATATGGGCCCAGCTGGAGCAC
GAGGCTGGAACCCAATTGCACAGGCAGACTGGATTACTGCTGCTGGGAATGAAAGAGAAT
CAAGAATTAAAGACAATCCAGGCCAATCTGTCGAGGCAGAGGGTAGAACACCAGTGTCTT
TCATCTGAGGAACTGAAGCAACGTTTCCCAAATATTCGGTTGCCCAGGGGAGAAGTGGGG
CTCTTGGACAATTCCGGAGGAGTTATCTATGCATATAAGGCCCTCAGAGCCCTGCAGGAT
GCAATTCGACAGCTAGGAGGCATAGTGCGTGACGGAGAGAAGGTGGTGGAGATAAACCCA
GGGCTACTGGTCACGGTGAAAACCACCTCCAGGAGCTACCAAGCTAAGAGCTTGGTCATC
ACAGCAGGTCCTTGGACCAACCAGCTCCTCCGTCCCCTGGGCATTGAGATGCCTCTCCAG
ACCCTGCGGATCAACGTGTGTTACTGGCGAGAGATGGTTCCTGGGAGCTATGGTGTGTCC
CAGGCCTTTCCGTGCTTCCTGTGGCTGGGCTTGTGTCCCCACCACATCTACGGACTGCCC
ACAGGAGAGTACCCAGGGCTGATGAAGGTCAGCTATCACCACGGCAACCACGCAGACCCT
GAGGAGCGGGACTGCCCCACAGCACGCACAGACATCGGAGACGTCCAGATCCTGAGCAGC
TTTGTCAGAGATCACTTACCTGATCTGAAGCCCGAGCCTGCTGTCATTGAGAGCTGCATG
TACACGAATACCCCTGATGAGCAGTTCATTCTCGATCGCCACCCAAAGTATGACAACATT
GTCATTGGTGCTGGATTCTCTGGGCACGGGTTCAAGCTGGCCCCTGTGGTGGGGAAGATC
CTGTATGAATTAAGCATGAAATTAACACCATCTTATGACTTGGCACCTTTTCGAATCAGC
CGTTTCCCAAGCCTGGCCAAAGCCCACCTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 390 |
| Molecular Weight
| 44065.515 |
| Theoretical pI
| 8.416 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Peroxisomal sarcosine oxidase
MAAQKDLWDAIVIGAGIQGCFTAYHLAKHRKRILLLEQFFLPHSRGSSHGQSRIIRKAYL
EDFYTRMMHECYQIWAQLEHEAGTQLHRQTGLLLLGMKENQELKTIQANLSRQRVEHQCL
SSEELKQRFPNIRLPRGEVGLLDNSGGVIYAYKALRALQDAIRQLGGIVRDGEKVVEINP
GLLVTVKTTSRSYQAKSLVITAGPWTNQLLRPLGIEMPLQTLRINVCYWREMVPGSYGVS
QAFPCFLWLGLCPHHIYGLPTGEYPGLMKVSYHHGNHADPEERDCPTARTDIGDVQILSS
FVRDHLPDLKPEPAVIESCMYTNTPDEQFILDRHPKYDNIVIGAGFSGHGFKLAPVVGKI
LYELSMKLTPSYDLAPFRISRFPSLGKAHL
|
| External Links |
|---|
| GenBank ID Protein
| 7157903 |
| UniProtKB/Swiss-Prot ID
| Q9P0Z9 |
| UniProtKB/Swiss-Prot Entry Name
| SOX_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF134593 |
| GeneCard ID
| PIPOX |
| GenAtlas ID
| PIPOX |
| HGNC ID
| HGNC:17804 |
| References |
|---|
| General References
| Not Available |