| Identification |
|---|
| HMDB Protein ID
| CDBP00098 |
| Secondary Accession Numbers
| Not Available |
| Name
| Acetylserotonin O-methyltransferase |
| Description
| Not Available |
| Synonyms
|
- ASMT
- Acetylserotonin O-methyltransferase
- HIOMT
- Hydroxyindole O-methyltransferase
|
| Gene Name
| ASMT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in O-methyltransferase activity |
| Specific Function
| Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity.
|
| GO Classification
|
| Biological Process |
| small molecule metabolic process |
| indolalkylamine biosynthetic process |
| melatonin biosynthetic process |
| translation |
| Cellular Component |
| cytosol |
| Function |
| o-methyltransferase activity |
| catalytic activity |
| transferase activity |
| transferase activity, transferring one-carbon groups |
| methyltransferase activity |
| Molecular Function |
| acetylserotonin O-methyltransferase activity |
| O-methyltransferase activity |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | melatonin biosynthesis | Not Available | Not Available | | Tryptophan Metabolism |    |  |
|
| Gene Properties |
|---|
| Chromosome Location
| X, Y |
| Locus
| Xp22.3 or Yp11.3 |
| SNPs
| ASMT |
| Gene Sequence
|
>1038 bp
ATGGGATCCTCAGAGGACCAGGCCTATCGCCTCCTTAATGACTACGCCAACGGCTTCATG
GTGTCCCAGGTTCTCTTCGCCGCCTGCGAGCTGGGCGTGTTTGACCTTCTCGCCGAGGCC
CCAGGGCCCCTGGACGTGGCGGCAGTGGCTGCAGGTGTGAGGGCCAGCGCCCATGGGACA
GAGCTCCTGCTGGACATCTGTGTGTCCCTGAAGCTGCTGAAAGTGGAGACGAGGGGAGGA
AAAGCTTTCTATCGAAACACAGAGCTGTCCAGCGACTACCTGACCACGGTCAGCCCGACG
TCACAATGCAGCATGCTGAAGTACATGGGCAGGACCAGCTACCGGTGCTGGGGCCACCTG
GCAGACGCCGTGAGAGAAGGAAGGAACCAGTACCTGGAGACGTTTGGCGTTCCCGCTGAA
GAGCTTTTTACGGCCATCTACAGGTCCGAGGGCGAGCGGCTACAGTTCATGCAAGCTCTG
CAGGAGGTCTGGAGCGTCAACGGGAGAAGCGTGCTGACCGCCTTTGACCTGTCAGTGTTC
CCACTTATGTGTGACCTTGGTGGTGGGGCTGGAGCTCTGGCTAAGGAATGCATGTCTCTG
TACCCTGGATGTAAGATCACCGTTTTTGACATCCCAGAAGTGGTGTGGACGGCAAAGCAG
CACTTCTCATTCCAGGAGGAAGAACAGATTGACTTCCAGGAAGGGGATTTCTTCAAAGAC
CCTCTTCCGGAAGCTGATCTGTACATCCTGGCCAGGGTCCTCCATGACTGGGCAGACGGA
AAGTGCTCACACCTGCTGGAGAGGATCTACCACACTTGCAAGCCAGGTGGTGGCATTCTG
GTAATTGAAAGCCTCCTGGATGAAGACAGGCGAGGTCCTCTGCTCACGCAGCTCTACTCT
CTGAACATGCTTGTGCAGACGGAAGGGCAGGAGAGGACCCCCACCCACTACCACATGCTC
CTCTCTTCTGCTGGCTTCAGAGACTTCCAGTTTAAGAAAACAGGAGCCATTTATGATGCC
ATTTTAGCCAGGAAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 345 |
| Molecular Weight
| 41660.34 |
| Theoretical pI
| 5.693 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Hydroxyindole O-methyltransferase
MGSSEDQAYRLLNDYANGFMVSQVLFAACELGVFDLLAEAPGPLDVAAVAAGVRASAHGT
ELLLDICVSLKLLKVETRGGKAFYRNTELSSDYLTTVSPTSQCSMLKYMGRTSYRCWGHL
ADAVREGRNQYLETFGVPAEELFTAIYRSEGERLQFMQALQEVWSVNGRSVLTAFDLSVF
PLMCDLGGGAGALAKECMSLYPGCKITVFDIPEVVWTAKQHFSFQEEEQIDFQEGDFFKD
PLPEADLYILARVLHDWADGKCSHLLERIYHTCKPGGGILVIESLLDEDRRGPLLTQLYS
LNMLVQTEGQERTPTHYHMLLSSAGFRDFQFKKTGAIYDAILARK
|
| External Links |
|---|
| GenBank ID Protein
| 57209912 |
| UniProtKB/Swiss-Prot ID
| P46597 |
| UniProtKB/Swiss-Prot Entry Name
| HIOM_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AL683807 |
| GeneCard ID
| ASMT |
| GenAtlas ID
| ASMT |
| HGNC ID
| HGNC:750 |
| References |
|---|
| General References
| Not Available |