| Identification |
|---|
| HMDB Protein ID
| CDBP00085 |
| Secondary Accession Numbers
| Not Available |
| Name
| Aldose reductase |
| Description
| Not Available |
| Synonyms
|
- AR
- Aldehyde reductase
- Aldo-keto reductase family 1 member B1
|
| Gene Name
| AKR1B1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity |
| Specific Function
| Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
|
| GO Classification
|
| Biological Process |
| small molecule metabolic process |
| C21-steroid hormone biosynthetic process |
| response to stress |
| daunorubicin metabolic process |
| doxorubicin metabolic process |
| carbohydrate metabolic process |
| Cellular Component |
| cytosol |
| nucleus |
| extracellular space |
| Function |
| catalytic activity |
| oxidoreductase activity |
| Molecular Function |
| electron carrier activity |
| alditol:NADP+ 1-oxidoreductase activity |
| glyceraldehyde oxidoreductase activity |
| Process |
| oxidation reduction |
| metabolic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Pentose and glucuronate interconversions | Not Available |  | | Fructose and mannose metabolism | Not Available |  | | Fructose and Mannose Degradation |    | | | Fructosuria |    | Not Available | | Fructose intolerance, hereditary |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| 7q35 |
| SNPs
| AKR1B1 |
| Gene Sequence
|
>951 bp
ATGGCAAGCCGTCTCCTGCTCAACAACGGCGCCAAGATGCCCATCCTGGGGTTGGGTACC
TGGAAGTCCCCTCCAGGGCAGGTGACTGAGGCCGTGAAGGTGGCCATTGACGTCGGGTAC
CGCCACATCGACTGTGCCCATGTGTACCAGAATGAGAATGAGGTGGGGGTGGCCATTCAG
GAGAAGCTCAGGGAGCAGGTGGTGAAGCGTGAGGAGCTCTTCATCGTCAGCAAGCTGTGG
TGCACGTACCATGAGAAGGGCCTGGTGAAAGGAGCCTGCCAGAAGACACTCAGCGACCTG
AAGCTGGACTACCTGGACCTCTACCTTATTCACTGGCCGACTGGCTTTAAGCCTGGGAAG
GAATTTTTCCCATTGGATGAGTCGGGCAATGTGGTTCCCAGTGACACCAACATTCTGGAC
ACGTGGGCGGCCATGGAAGAGCTGGTGGATGAAGGGCTGGTGAAAGCTATTGGCATCTCC
AACTTCAACCATCTCCAGGTGGAGATGATCTTAAACAAACCTGGCTTGAAGTATAAGCCT
GCAGTTAACCAGATTGAGTGCCACCCATATCTCACTCAGGAGAAGTTAATCCAGTACTGC
CAGTCCAAAGGCATCGTGGTGACCGCCTACAGCCCCCTCGGCTCTCCTGACAGGCCCTGG
GCCAAGCCCGAGGACCCTTCTCTCCTGGAGGATCCCAGGATCAAGGCGATCGCAGCCAAG
CACAATAAAACTACAGCCCAGGTCCTGATCCGGTTCCCCATGCAGAGGAACTTGGTGGTG
ATCCCCAAGTCTGTGACACCAGAACGCATTGCTGAGAACTTTAAGGTCTTTGACTTTGAA
CTGAGCAGCCAGGATATGACCACCTTACTCAGCTACAACAGGAACTGGAGGGTCTGTGCC
TTGTTGAGCTGTACCTCCCACAAGGATTACCCCTTCCATGAAGAGTTTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 316 |
| Molecular Weight
| 35853.125 |
| Theoretical pI
| 6.982 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Aldose reductase
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF
|
| External Links |
|---|
| GenBank ID Protein
| 2687578 |
| UniProtKB/Swiss-Prot ID
| P15121 |
| UniProtKB/Swiss-Prot Entry Name
| ALDR_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF032455 |
| GeneCard ID
| AKR1B1 |
| GenAtlas ID
| AKR1B1 |
| HGNC ID
| HGNC:381 |
| References |
|---|
| General References
| Not Available |