| Identification |
|---|
| HMDB Protein ID
| CDBP00076 |
| Secondary Accession Numbers
| Not Available |
| Name
| Prostaglandin E synthase |
| Description
| Not Available |
| Synonyms
|
- MGST1-L1
- Microsomal glutathione S-transferase 1-like 1
- p53-induced gene 12 protein
- Microsomal prostaglandin E synthase 1
- MPGES-1
|
| Gene Name
| PTGES |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in prostaglandin-E synthase activity |
| Specific Function
| Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).
|
| GO Classification
|
| Biological Process |
| signal transduction |
| negative regulation of cell proliferation |
| prostaglandin biosynthetic process |
| Cellular Component |
| cytoplasm |
| nuclear envelope lumen |
| integral to membrane |
| Molecular Function |
| prostaglandin-E synthase activity |
| glutathione binding |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein (Potential)
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Arachidonic Acid Metabolism |    |  | | Leukotriene C4 Synthesis Deficiency |    | Not Available | | Piroxicam Action Pathway |    | Not Available | | Acetylsalicylic Acid Action Pathway |    | Not Available | | Etodolac Action Pathway |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 9 |
| Locus
| 9q34.3 |
| SNPs
| PTGES |
| Gene Sequence
|
>459 bp
ATGCCTGCCCACAGCCTGGTGATGAGCAGCCCGGCCCTCCCGGCCTTCCTGCTCTGCAGC
ACGCTGCTGGTCATCAAGATGTACGTGGTGGCCATCATCACGGGCCAAGTGAGGCTGCGG
AAGAAGGCCTTTGCCAACCCCGAGGATGCCCTGAGACACGGAGGCCCCCAGTATTGCAGG
AGCGACCCCGACGTGGAACGCTGCCTCAGGGCCCACCGGAACGACATGGAGACCATCTAC
CCCTTCCTTTTCCTGGGCTTCGTCTACTCCTTTCTGGGTCCTAACCCTTTTGTCGCCTGG
ATGCACTTCCTGGTCTTCCTCGTGGGCCGTGTGGCACACACCGTGGCCTACCTGGGGAAG
CTGCGGGCACCCATCCGCTCCGTGACCTACACCCTGGCCCAGCTCCCCTGCGCCTCCATG
GCTCTGCAGATCCTCTGGGAAGCGGCCCGCCACCTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 152 |
| Molecular Weight
| 17102.135 |
| Theoretical pI
| 9.493 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Prostaglandin E synthase
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCR
SDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGK
LRAPIRSVTYTLAQLPCASMALQILWEAARHL
|
| External Links |
|---|
| GenBank ID Protein
| 4758910 |
| UniProtKB/Swiss-Prot ID
| O14684 |
| UniProtKB/Swiss-Prot Entry Name
| PTGES_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_004878.4 |
| GeneCard ID
| PTGES |
| GenAtlas ID
| PTGES |
| HGNC ID
| HGNC:9599 |
| References |
|---|
| General References
| Not Available |