Cannabis Compound Database: Showing Protein 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (CDBP00075)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 compounds

Identification

HMDB Protein ID

CDBP00075

Secondary Accession Numbers

Not Available

Name

15-hydroxyprostaglandin dehydrogenase [NAD(+)]

Description

Not Available

Synonyms

15-PGDH
Prostaglandin dehydrogenase 1

Gene Name

HPGD

Protein Type

Enzyme

Biological Properties

General Function

Involved in oxidoreductase activity

Specific Function

Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells.

GO Classification

Biological Process
female pregnancy
ovulation
lipoxygenase pathway
parturition
prostaglandin metabolic process
oxidation-reduction process
transforming growth factor beta receptor signaling pathway
ductus arteriosus closure
thrombin receptor signaling pathway
negative regulation of cell cycle
Cellular Component
cytosol
cytoplasm
nucleus
Function
binding
catalytic activity
oxidoreductase activity
Molecular Function
protein homodimerization activity
NAD+ binding
nucleotide binding
15-hydroxyprostaglandin dehydrogenase (NAD+) activity
prostaglandin E receptor activity
oxidoreductase activity
Process
metabolic process
oxidation reduction

Cellular Location

Cytoplasm

Pathways

Name	SMPDB/Pathwhiz	KEGG
Transcriptional misregulation in cancer	Not Available

Gene Properties

Chromosome Location

Locus

4q34-q35

SNPs

HPGD

Gene Sequence

>801 bp
ATGCACGTGAACGGCAAAGTGGCGCTGGTGACCGGCGCGGCTCAGGGCATAGGCAGAGCC
TTTGCAGAGGCGCTGCTGCTTAAGGGCGCCAAGGTAGCGCTGGTGGATTGGAATCTTGAA
GCAGGTGTACAGTGTAAAGCTGCCCTGGATGAGCAGTTTGAACCTCAGAAGACTCTGTTC
ATCCAGTGCGATGTGGCTGACCAGCAACAACTGAGAGACACTTTTAGAAAAGTTGTAGAC
CACTTTGGAAGACTGGACATTTTGGTCAATAATGCTGGAGTGAATAATGAGAAAAACTGG
GAAAAAACTCTGCAAATTAATTTGGTTTCTGTTATCAGTGGAACCTATCTTGGTTTGGAT
TACATGAGTAAGCAAAATGGAGGTGAAGGCGGCATCATTATCAATATGTCATCTTTAGCA
GGACTCATGCCCGTTGCACAGCAGCCGGTTTATTGTGCTTCAAAGCATGGCATAGTTGGA
TTCACACGCTCAGCAGCGTTGGCTGCTAATCTTATGAACAGTGGTGTGAGACTGAATGCC
ATTTGTCCAGGCTTTGTTAACACAGCCATCCTTGAATCAATTGAAAAAGAAGAAAACATG
GGACAATATATAGAATATAAGGATCATATCAAGGATATGATTAAATACTATGGAATTTTG
GACCCACCATTGATTGCCAATGGATTGATAACACTCATTGAAGATGATGCTTTAAATGGT
GCTATTATGAAGATCACAACTTCTAAGGGAATTCATTTTCAAGACTATGATACAACTCCA
TTTCAAGCAAAAACCCAATGA

Protein Properties

Number of Residues

266

Molecular Weight

28977.105

Theoretical pI

5.857

Pfam Domain Function

adh_short (PF00106 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>15-hydroxyprostaglandin dehydrogenase [NAD+]
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLF
IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLD
YMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNA
ICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNG
AIMKITTSKGIHFQDYDTTPFQAKTQ

External Links

GenBank ID Protein

189054417

UniProtKB/Swiss-Prot ID

P15428

UniProtKB/Swiss-Prot Entry Name

PGDH_HUMAN

PDB IDs