| Identification |
|---|
| HMDB Protein ID
| CDBP00065 |
| Secondary Accession Numbers
| Not Available |
| Name
| Group XIIA secretory phospholipase A2 |
| Description
| Not Available |
| Synonyms
|
- GXII sPLA2
- Phosphatidylcholine 2-acylhydrolase 12A
- sPLA2-XII
|
| Gene Name
| PLA2G12A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phospholipase A2 activity |
| Specific Function
| PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine.
|
| GO Classification
|
| Biological Process |
| phosphatidylcholine acyl-chain remodeling |
| phosphatidylethanolamine acyl-chain remodeling |
| phosphatidylinositol acyl-chain remodeling |
| phosphatidylserine acyl-chain remodeling |
| lipid catabolic process |
| phosphatidic acid biosynthetic process |
| phosphatidylglycerol acyl-chain remodeling |
| Cellular Component |
| endoplasmic reticulum |
| Golgi apparatus |
| extracellular region |
| Component |
| extracellular region |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| hydrolase activity, acting on ester bonds |
| binding |
| catalytic activity |
| hydrolase activity |
| calcium ion binding |
| carboxylesterase activity |
| phospholipase a2 activity |
| Molecular Function |
| calcium-dependent phospholipase A2 activity |
| calcium ion binding |
| Process |
| metabolic process |
| primary metabolic process |
| lipid metabolic process |
| lipid catabolic process |
| organophosphate metabolic process |
| phospholipid metabolic process |
|
| Cellular Location
|
- Cytoplasm
- Secreted
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glycerophospholipid metabolism | Not Available |  | | Ether lipid metabolism | Not Available |  | | Linoleic acid metabolism | Not Available |  | | alpha-Linolenic acid metabolism | Not Available |  | | Vascular smooth muscle contraction | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| 4q25 |
| SNPs
| PLA2G12A |
| Gene Sequence
|
>570 bp
ATGGCCCTGCTCTCGCGCCCCGCGCTCACCCTCCTGCTCCTCCTCATGGCCGCTGTTGTC
AGGTGCCAGGAGCAGGCCCAGACCACCGACTGGAGAGCCACCCTGAAGACCATCCGGAAC
GGCGTTCATAAGATAGACACGTACCTGAACGCCGCCTTGGACCTCCTGGGAGGCGAGGAC
GGTCTCTGCCAGTATAAATGCAGTGACGGATCTAAGCCTTTCCCACGTTATGGTTATAAA
CCCTCCCCACCGAATGGATGTGGCTCTCCACTGTTTGGTGTTCATCTTAACATTGGTATC
CCTTCCCTGACAAAGTGTTGCAACCAACACGACAGGTGCTATGAGACCTGTGGCAAAAGC
AAGAATGACTGTGATGAAGAATTCCAGTATTGCCTCTCCAAGATCTGCCGAGATGTACAG
AAAACACTAGGACTAACTCAGCATGTTCAGGCATGTGAAACAACAGTGGAGCTCTTGTTT
GACAGTGTTATACATTTAGGTTGTAAACCATATCTGGACAGCCAACGAGCCGCATGCAGG
TGTCATTATGAAGAAAAAACTGATCTTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 189 |
| Molecular Weight
| 21066.99 |
| Theoretical pI
| 7.237 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Group XIIA secretory phospholipase A2
MALLSRPALTLLLLLMAAVVRCQEQAQTTDWRATLKTIRNGVHKIDTYLNAALDLLGGED
GLCQYKCSDGSKPFPRYGYKPSPPNGCGSPLFGVHLNIGIPSLTKCCNQHDRCYETCGKS
KNDCDEEFQYCLSKICRDVQKTLGLTQHVQACETTVELLFDSVIHLGCKPYLDSQRAACR
CHYEEKTDL
|
| External Links |
|---|
| GenBank ID Protein
| 12276062 |
| UniProtKB/Swiss-Prot ID
| Q9BZM1 |
| UniProtKB/Swiss-Prot Entry Name
| PG12A_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF306567 |
| GeneCard ID
| PLA2G12A |
| GenAtlas ID
| PLA2G12A |
| HGNC ID
| HGNC:18554 |
| References |
|---|
| General References
| Not Available |