| Identification |
|---|
| HMDB Protein ID
| CDBP00064 |
| Secondary Accession Numbers
| Not Available |
| Name
| Acyl-protein thioesterase 2 |
| Description
| Not Available |
| Synonyms
|
- APT-2
- LPL-II
- LysoPLA II
- Lysophospholipase II
|
| Gene Name
| LYPLA2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in hydrolase activity |
| Specific Function
| May hydrolyze fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has lysophospholipase activity (By similarity). Deacylates GAP43.
|
| GO Classification
|
| Biological Process |
| fatty acid metabolic process |
| Cellular Component |
| cytoplasm |
| Function |
| catalytic activity |
| hydrolase activity |
| Molecular Function |
| hydrolase activity |
|
| Cellular Location
|
- Cytoplasm (Probable)
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glycerophospholipid metabolism | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1p36.11 |
| SNPs
| LYPLA2 |
| Gene Sequence
|
>696 bp
ATGTGTGGTAACACCATGTCTGTGCCCCTGCTCACCGATGCTGCCACCGTGTCTGGAGCT
GAGCGGGAAACGGCCGCGGTTATTTTTTTACATGGACTTGGAGACACAGGGCACAGCTGG
GCTGACGCCCTCTCCACCATCCGGCTCCCTCACGTCAAGTACATCTGTCCCCATGCGCCT
AGGATCCCTGTGACCCTCAACATGAAGATGGTGATGCCCTCCTGGTTTGACCTGATGGGG
CTGAGTCCAGATGCCCCAGAGGACGAGGCTGGCATCAAGAAGGCAGCAGAGAACATCAAG
GCCTTGATTGAGCATGAAATGAAGAACGGGATCCCTGCCAATCGAATCGTCCTGGGAGGC
TTTTCACAGGGCGGGGCCCTGTCCCTCTACACGGCCCTCACCTGCCCCCACCCTCTGGCT
GGCATCGTGGCGTTGAGCTGCTGGCTGCCTCTGCACCGGGCCTTCCCCCAGGCAGCTAAT
GGCAGTGCCAAGGACCTGGCCATACTCCAGTGCCATGGGGAGCTGGACCCCATGGTGCCC
GTACGGTTTGGGGCCCTGACGGCTGAGAAGCTCCGGTCTGTTGTCACACCTGCCAGGGTC
CAGTTCAAGACATACCCGGGTGTCATGCACAGCTCCTGTCCTCAGGAGATGGCAGCTGTG
AAGGAATTTCTTGAGAAGCTGCTGCCTCCTGTCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 231 |
| Molecular Weight
| 24736.71 |
| Theoretical pI
| 7.222 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Acyl-protein thioesterase 2
MCGNTMSVPLLTDAATVSGAERETAAVIFLHGLGDTGHSWADALSTIRLPHVKYICPHAP
RIPVTLNMKMVMPSWFDLMGLSPDAPEDEAGIKKAAENIKALIEHEMKNGIPANRIVLGG
FSQGGALSLYTALTCPHPLAGIVALSCWLPLHRAFPQAANGSAKDLAILQCHGELDPMVP
VRFGALTAEKLRSVVTPARVQFKTYPGVMHSSCPQEMAAVKEFLEKLLPPV
|
| External Links |
|---|
| GenBank ID Protein
| 9966764 |
| UniProtKB/Swiss-Prot ID
| O95372 |
| UniProtKB/Swiss-Prot Entry Name
| LYPA2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_007260.2 |
| GeneCard ID
| LYPLA2 |
| GenAtlas ID
| LYPLA2 |
| HGNC ID
| HGNC:6738 |
| References |
|---|
| General References
| Not Available |