Cannabis Compound Database: Showing Protein Group 10 secretory phospholipase A2 (CDBP00061)

Identification Biological properties Gene properties Protein properties External links References XML Show 45 compounds

Identification

HMDB Protein ID

CDBP00061

Secondary Accession Numbers

Not Available

Name

Group 10 secretory phospholipase A2

Description

Not Available

Synonyms

GX sPLA2
Group X secretory phospholipase A2
Phosphatidylcholine 2-acylhydrolase 10
sPLA2-X

Gene Name

PLA2G10

Protein Type

Enzyme

Biological Properties

General Function

Involved in phospholipase A2 activity

Specific Function

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine.

GO Classification

Biological Process
lipid catabolic process
positive regulation of macrophage derived foam cell differentiation
lysophospholipid transport
negative regulation of cholesterol efflux
positive regulation of arachidonic acid secretion
positive regulation of cellular protein metabolic process
positive regulation of lipid storage
positive regulation of prostaglandin secretion
axon guidance
arachidonic acid metabolic process
phosphatidic acid biosynthetic process
negative regulation of sequence-specific DNA binding transcription factor activity
cholesterol homeostasis
phosphatidylcholine acyl-chain remodeling
phosphatidylglycerol acyl-chain remodeling
phosphatidylethanolamine acyl-chain remodeling
regulation of macrophage activation
phosphatidylinositol acyl-chain remodeling
phosphatidylserine acyl-chain remodeling
Cellular Component
extracellular region
Function
cation binding
metal ion binding
hydrolase activity, acting on ester bonds
binding
catalytic activity
hydrolase activity
calcium ion binding
carboxylesterase activity
phospholipase a2 activity
ion binding
Molecular Function
phospholipase A2 activity
calcium ion binding
Process
phospholipid metabolic process
metabolic process
primary metabolic process
lipid metabolic process
lipid catabolic process
organophosphate metabolic process

Cellular Location

Secreted

Pathways

Name	SMPDB/Pathwhiz	KEGG
Glycerophospholipid metabolism	Not Available
Ether lipid metabolism	Not Available
Linoleic acid metabolism	Not Available
alpha-Linolenic acid metabolism	Not Available
Vascular smooth muscle contraction	Not Available

Gene Properties

Chromosome Location

Locus

16p13.1-p12

SNPs

PLA2G10

Gene Sequence

>498 bp
ATGGGGCCGCTACCTGTGTGCCTGCCAATCATGCTGCTCCTGCTACTGCCGTCGCTGCTG
CTGCTGCTGCTTCTACCTGGCCCCGGGTCCGGCGAGGCCTCCAGGATATTACGTGTGCAC
CGGCGTGGGATCCTGGAACTGGCAGGAACTGTGGGTTGTGTTGGTCCCCGAACCCCCATC
GCCTATATGAAATATGGTTGCTTTTGTGGCTTGGGAGGCCATGGCCAGCCCCGCGATGCC
ATTGACTGGTGCTGCCATGGCCACGACTGTTGTTACACTCGAGCTGAGGAGGCCGGCTGC
AGCCCCAAGACAGAGCGCTACTCCTGGCAGTGCGTCAATCAGAGCGTCCTGTGCGGACCG
GCAGAGAACAAATGCCAAGAACTGTTGTGCAAGTGTGACCAGGAGATTGCTAACTGCTTA
GCCCAAACTGAGTACAACTTAAAGTACCTCTTCTACCCCCAGTTCCTATGTGAGCCGGAC
TCGCCCAAGTGTGACTGA

Protein Properties

Number of Residues

165

Molecular Weight

18153.04

Theoretical pI

6.475

Pfam Domain Function

Phospholip_A2_1 (PF00068 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Group 10 secretory phospholipase A2
MGPLPVCLPIMLLLLLPSLLLLLLLPGPGSGEASRILRVHRRGILELAGTVGCVGPRTPI
AYMKYGCFCGLGGHGQPRDAIDWCCHGHDCCYTRAEEAGCSPKTERYSWQCVNQSVLCGP
AENKCQELLCKCDQEIANCLAQTEYNLKYLFYPQFLCEPDSPKCD

External Links

GenBank ID Protein

Not Available

UniProtKB/Swiss-Prot ID

O15496

UniProtKB/Swiss-Prot Entry Name

PA2GX_HUMAN

PDB IDs