| Identification |
|---|
| HMDB Protein ID
| CDBP00056 |
| Secondary Accession Numbers
| Not Available |
| Name
| Calcium-dependent phospholipase A2 |
| Description
| Not Available |
| Synonyms
|
- Group V phospholipase A2
- PLA2-10
- Phosphatidylcholine 2-acylhydrolase 5
|
| Gene Name
| PLA2G5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phospholipase A2 activity |
| Specific Function
| PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L-alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L-alpha-1-stearoyl-2-arachidonyl phosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiac muscle.
|
| GO Classification
|
| Biological Process |
| response to cytokine stimulus |
| phosphatidylglycerol acyl-chain remodeling |
| response to cAMP |
| phosphatidylcholine acyl-chain remodeling |
| phosphatidylethanolamine acyl-chain remodeling |
| phosphatidylinositol acyl-chain remodeling |
| phosphatidylserine acyl-chain remodeling |
| lipid catabolic process |
| arachidonic acid secretion |
| phosphatidic acid biosynthetic process |
| platelet activating factor biosynthetic process |
| leukotriene biosynthetic process |
| Cellular Component |
| cell surface |
| plasma membrane |
| Golgi apparatus |
| perinuclear region of cytoplasm |
| extracellular region |
| Function |
| carboxylesterase activity |
| phospholipase a2 activity |
| ion binding |
| cation binding |
| metal ion binding |
| hydrolase activity, acting on ester bonds |
| binding |
| catalytic activity |
| hydrolase activity |
| calcium ion binding |
| Molecular Function |
| calcium-dependent phospholipase A2 activity |
| calcium ion binding |
| heparin binding |
| Process |
| metabolic process |
| primary metabolic process |
| lipid metabolic process |
| lipid catabolic process |
| organophosphate metabolic process |
| phospholipid metabolic process |
|
| Cellular Location
|
- Secreted
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glycerophospholipid metabolism | Not Available |  | | Ether lipid metabolism | Not Available |  | | Linoleic acid metabolism | Not Available |  | | alpha-Linolenic acid metabolism | Not Available |  | | Vascular smooth muscle contraction | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1p36-p34 |
| SNPs
| PLA2G5 |
| Gene Sequence
|
>417 bp
ATGAAAGGCCTCCTCCCACTGGCTTGGTTCCTGGCTTGTAGTGTGCCTGCTGTGCAAGGA
GGCTTGCTGGACCTAAAATCAATGATCGAGAAGGTGACAGGGAAGAACGCCCTGACAAAC
TACGGCTTCTACGGCTGTTACTGCGGCTGGGGCGGCCGAGGAACCCCCAAGGATGGCACC
GATTGGTGCTGTTGGGCGCATGACCACTGCTATGGGCGGCTGGAGGAGAAGGGCTGCAAC
ATTCGCACACAGTCCTACAAATACAGATTCGCGTGGGGCGTGGTCACCTGCGAGCCCGGG
CCCTTCTGCCATGTGAACCTCTGTGCCTGTGACCGGAAGCTCGTCTACTGCCTCAAGAGA
AACCTACGGAGCTACAACCCACAGTACCAATACTTTCCCAACATCCTCTGCTCCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 138 |
| Molecular Weight
| 15674.065 |
| Theoretical pI
| 8.411 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Calcium-dependent phospholipase A2
MKGLLPLAWFLACSVPAVQGGLLDLKSMIEKVTGKNALTNYGFYGCYCGWGGRGTPKDGT
DWCCWAHDHCYGRLEEKGCNIRTQSYKYRFAWGVVTCEPGPFCHVNLCACDRKLVYCLKR
NLRSYNPQYQYFPNILCS
|
| External Links |
|---|
| GenBank ID Protein
| 10862735 |
| UniProtKB/Swiss-Prot ID
| P39877 |
| UniProtKB/Swiss-Prot Entry Name
| PA2G5_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AL158172 |
| GeneCard ID
| PLA2G5 |
| GenAtlas ID
| PLA2G5 |
| HGNC ID
| HGNC:9038 |
| References |
|---|
| General References
| Not Available |