Cannabis Compound Database: Showing Protein Acyl-protein thioesterase 1 (CDBP00054)

Identification Biological properties Gene properties Protein properties External links References XML Show 19 compounds

Identification

HMDB Protein ID

CDBP00054

Secondary Accession Numbers

Not Available

Name

Acyl-protein thioesterase 1

Description

Not Available

Synonyms

APT-1
LPL-I
LysoPLA I
Lysophospholipase 1
Lysophospholipase I
hAPT1

Gene Name

LYPLA1

Protein Type

Enzyme

Biological Properties

General Function

Involved in hydrolase activity

Specific Function

Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity and also low lysophospholipase activity.

GO Classification

Biological Process
nitric oxide metabolic process
regulation of nitric-oxide synthase activity
small molecule metabolic process
fatty acid metabolic process
Cellular Component
cytosol
mitochondrion
Function
catalytic activity
hydrolase activity
Molecular Function
lysophospholipase activity
palmitoyl-(protein) hydrolase activity

Cellular Location

Cytoplasm

Pathways

Name	SMPDB/Pathwhiz	KEGG
Phospholipid Biosynthesis
Glycerophospholipid metabolism	Not Available

Gene Properties

Chromosome Location

Locus

8q11.23

SNPs

LYPLA1

Gene Sequence

>693 bp
ATGTGCGGCAATAACATGTCAACCCCGCTGCCCGCCATCGTGCCCGCCGCCCGGAAGGCC
ACCGCTGCGGTGATTTTCCTGCATGGATTGGGAGATACTGGGCACGGATGGGCAGAAGCC
TTTGCAGGTATCAGAAGTTCACATATCAAATATATCTGCCCGCATGCGCCTGTTAGGCCT
GTTACATTAAATATGAACGTGGCTATGCCTTCATGGTTTGATATTATTGGGCTTTCACCA
GATTCACAGGAGGATGAATCTGGGATTAAACAGGCAGCAGAAAATATAAAAGCTTTGATT
GATCAAGAAGTGAAGAATGGCATTCCTTCTAACAGAATTATTTTGGGAGGGTTTTCTCAG
GGAGGAGCTTTATCTTTATATACTGCCCTTACCACACAGCAGAAACTGGCAGGTGTCACT
GCACTCAGTTGCTGGCTTCCACTTCGGGCTTCCTTTCCACAGGGTCCTATCGGTGGTGCT
AATAGAGATATTTCTATTCTCCAGTGCCACGGGGATTGTGACCCTTTGGTTCCCCTGATG
TTTGGTTCTCTTACGGTGGAAAAACTAAAAACATTGGTGAATCCAGCCAATGTGACCTTT
AAAACCTATGAAGGTATGATGCACAGTTCGTGTCAACAGGAAATGATGGATGTCAAGCAA
TTCATTGATAAACTCCTACCTCCAATTGATTGA

Protein Properties

Number of Residues

230

Molecular Weight

24669.355

Theoretical pI

6.771

Pfam Domain Function

Abhydrolase_2 (PF02230 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Acyl-protein thioesterase 1
MCGNNMSTPLPAIVPAARKATAAVIFLHGLGDTGHGWAEAFAGIRSSHIKYICPHAPVRP
VTLNMNVAMPSWFDIIGLSPDSQEDESGIKQAAENIKALIDQEVKNGIPSNRIILGGFSQ
GGALSLYTALTTQQKLAGVTALSCWLPLRASFPQGPIGGANRDISILQCHGDCDPLVPLM
FGSLTVEKLKTLVNPANVTFKTYEGMMHSSCQQEMMDVKQFIDKLLPPID

External Links

GenBank ID Protein

5453722

UniProtKB/Swiss-Prot ID

O75608

UniProtKB/Swiss-Prot Entry Name

LYPA1_HUMAN

PDB IDs