Cannabis Compound Database: Showing Protein Hydroxymethylglutaryl-CoA synthase, mitochondrial (CDBP00038)

Identification Biological properties Gene properties Protein properties External links References XML Show 6 compounds

Identification

HMDB Protein ID

CDBP00038

Secondary Accession Numbers

Not Available

Name

Hydroxymethylglutaryl-CoA synthase, mitochondrial

Description

Not Available

Synonyms

3-hydroxy-3-methylglutaryl coenzyme A synthase
HMG-CoA synthase

Gene Name

HMGCS2

Protein Type

Enzyme

Biological Properties

General Function

Involved in hydroxymethylglutaryl-CoA synthase activity

Specific Function

This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.

GO Classification

Biological Process
cellular response to amino acid stimulus
lung development
ketone body biosynthetic process
cellular response to glucocorticoid stimulus
adipose tissue development
midgut development
response to testosterone stimulus
multicellular organismal response to stress
response to growth hormone stimulus
response to linoleic acid
liver development
response to monosaccharide stimulus
response to prostaglandin F stimulus
response to drug
response to temperature stimulus
response to ethanol
response to triglyceride
response to metal ion
cellular lipid metabolic process
response to nutrient
response to cAMP
response to starvation
cellular response to lipopolysaccharide
cellular response to insulin stimulus
isoprenoid biosynthetic process
brain development
response to glucagon stimulus
kidney development
cholesterol biosynthetic process
cellular response to fatty acid
Cellular Component
mitochondrial matrix
mitochondrial inner membrane
Function
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
hydroxymethylglutaryl-coa synthase activity
catalytic activity
transferase activity
transferase activity, transferring acyl groups
Molecular Function
hydroxymethylglutaryl-CoA synthase activity
Process
metabolic process
primary metabolic process
lipid metabolic process
cellular lipid metabolic process
isoprenoid metabolic process
isoprenoid biosynthetic process

Cellular Location

Mitochondrion

Pathways

Name	SMPDB/Pathwhiz	KEGG
(R)-mevalonate biosynthesis	Not Available	Not Available
Synthesis and degradation of ketone bodies	Not Available
Butanoate metabolism	Not Available
Terpenoid backbone biosynthesis	Not Available
PPAR signaling pathway	Not Available

Gene Properties

Chromosome Location

Locus

1p13-p12

SNPs

HMGCS2

Gene Sequence

>1527 bp
ATGCAGCGTCTGTTGACTCCAGTGAAGCGCATTCTGCAACTGACAAGAGCGGTGCAGGAA
ACCTCCCTCACACCTGCTCGCCTGCTCCCAGTAGCCCACCAAAGGTTTTCTACAGCCTCT
GCTGTCCCCCTGGCCAAAACAGATACTTGGCCAAAGGACGTGGGCATCCTGGCCCTGGAG
GTCTACTTCCCAGCCCAATATGTGGACCAAACTGACCTGGAGAAGTATAACAATGTGGAA
GCAGGAAAGTATACAGTGGGCTTGGGCCAGACCCGTATGGGCTTCTGCTCAGTCCAAGAG
GACATCAACTCCCTGTGCCTGACGGTGGTGCAACGGCTGATGGAGCGCATACAGCTCCCA
TGGGACTCTGTGGGCAGGCTGGAAGTAGGCACTGAGACCATCATTGACAAGTCCAAAGCT
GTCAAAACAGTGCTCATGGAACTCTTCCAGGATTCAGGCAATACTGATATTGAGGGCATA
GATACCACCAATGCCTGCTACGGTGGTACTGCCTCCCTCTTCAATGCTGCCAACTGGATG
GAGTCCAGTTCCTGGGATGGTCGTTATGCCATGGTGGTCTGTGGAGACATTGCCGTCTAT
CCCAGTGGTAATGCTCGTCCCACAGGTGGGGCCGGAGCTGTGGCTATGCTGATTGGGCCC
AAGGCCCCTCTGGCCCTGGAGCGAGGGCTGAGGGGAACCCATATGGAGAATGTGTATGAC
TTCTACAAACCAAATTTGGCCTCGGAGTACCCAATAGTGGATGGGAAGCTTTCCATCCAG
TGCTACTTGCGGGCCTTGGATCGATGTTACACATCATACCGTAAAAAAATCCAGAATCAG
TGGAAGCAAGCTGGCAGCGATCGACCCTTCACCCTTGACGATTTACAGTACATGATCTTT
CATACACCCTTTTGCAAGATGGTCCAGAAGTCTCTGGCTCGCCTGATGTTCAATGACTTC
CTGTCAGCCAGCAGTGACACACAAACCAGCTTATATAAGGGGCTGGAGGCTTTCGGGGGG
CTAAAGCTGGAAGACACCTACACCAACAAGGACCTGGATAAAGCACTTCTAAAGGCCTCT
CAGGACATGTTCGACAAGAAAACCAAGGCTTCCCTTTACCTCTCCACTCACAATGGGAAC
ATGTACACCTCATCCCTGTACGGGTGCCTGGCCTCGCTTCTGTCCCACCACTCTGCCCAA
GAACTGGCTGGCTCCAGGATTGGTGCCTTCTCTTATGGCTCTGGTTTAGCAGCAAGTTTC
TTTTCATTTCGAGTATCCCAGGATGCTGCTCCAGGCTCTCCCCTGGACAAGTTGGTGTCC
AGCACATCAGACCTGCCAAAACGCCTAGCCTCCCGAAAGTGTGTGTCTCCTGAGGAGTTC
ACAGAAATAATGAACCAAAGAGAGCAATTCTACCATAAGGTGAATTTCTCCCCACCTGGT
GACACAAACAGCCTTTTCCCAGGTACTTGGTACCTGGAGCGAGTGGACGAGCAGCATCGC
CGAAAGTATGCCCGGCGTCCCGTCTAA

Protein Properties

Number of Residues

508

Molecular Weight

52481.065

Theoretical pI

7.877

Pfam Domain Function

HMG_CoA_synt_C (PF08540 )
HMG_CoA_synt_N (PF01154 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Hydroxymethylglutaryl-CoA synthase, mitochondrial
MQRLLTPVKRILQLTRAVQETSLTPARLLPVAHQRFSTASAVPLAKTDTWPKDVGILALE
VYFPAQYVDQTDLEKYNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERIQLP
WDSVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWM
ESSSWDGRYAMVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLALERGLRGTHMENVYD
FYKPNLASEYPIVDGKLSIQCYLRALDRCYTSYRKKIQNQWKQAGSDRPFTLDDLQYMIF
HTPFCKMVQKSLARLMFNDFLSASSDTQTSLYKGLEAFGGLKLEDTYTNKDLDKALLKAS
QDMFDKKTKASLYLSTHNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASF
FSFRVSQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEFTEIMNQREQFYHKVNFSPPG
DTNSLFPGTWYLERVDEQHRRKYARRPV

External Links

GenBank ID Protein

56205097

UniProtKB/Swiss-Prot ID

P54868

UniProtKB/Swiss-Prot Entry Name

HMCS2_HUMAN

PDB IDs