| Identification |
|---|
| HMDB Protein ID
| CDBP00031 |
| Secondary Accession Numbers
| Not Available |
| Name
| 3-ketoacyl-CoA thiolase, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- Acetyl-CoA acyltransferase
- Beta-ketothiolase
- Mitochondrial 3-oxoacyl-CoA thiolase
- T1
|
| Gene Name
| ACAA2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in transferase activity, transferring acyl groups other than amino-acyl groups |
| Specific Function
| Abolishes BNIP3-mediated apoptosis and mitochondrial damage.
|
| GO Classification
|
| Biological Process |
| negative regulation of apoptotic process |
| cholesterol biosynthetic process |
| acetyl-CoA metabolic process |
| fatty acid beta-oxidation |
| Cellular Component |
| mitochondrion |
| mitochondrial inner membrane |
| Function |
| transferase activity, transferring acyl groups |
| transferase activity, transferring acyl groups other than amino-acyl groups |
| catalytic activity |
| transferase activity |
| Molecular Function |
| acetyl-CoA C-acyltransferase activity |
| Process |
| metabolic process |
|
| Cellular Location
|
- Mitochondrion
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Fatty acid elongation | Not Available |  | | Fatty Acid Elongation In Mitochondria |    | | | Long-chain-3-hydroxyacyl-coa dehydrogenase deficiency (LCHAD) |    | Not Available | | Fatty acid Metabolism |    |  | | Ethylmalonic Encephalopathy |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 18 |
| Locus
| 18q21.1 |
| SNPs
| ACAA2 |
| Gene Sequence
|
>1194 bp
ATGGCTCTGCTCCGAGGTGTGTTTGTAGTTGCTGCTAAGCGAACGCCCTTTGGAGCTTAC
GGAGGCCTTCTGAAAGACTTCACTGCTACTGACTTGTCTGAATTTGCTGCCAAGGCTGCC
TTGTCTGCTGGCAAAGTCTCACCTGAAACAGTTGACAGTGTGATTATGGGCAATGTCCTG
CAGAGTTCTTCAGATGCTATATATTTGGCAAGGCATGTTGGTTTGCGTGTGGGAATCCCA
AAGGAGACCCCAGCTCTCACGATTAATAGGCTCTGTGGTTCTGGTTTTCAGTCCATTGTG
AATGGATGTCAGGAAATTTGTGTTAAAGAAGCTGAAGTTGTTTTATGTGGAGGAACCGAA
AGCATGAGCCAAGCTCCCTACTGTGTCAGAAATGTGCGTTTTGGAACCAAGCTTGGATCA
GATATCAAGCTGGAAGATTCTTTATGGGTATCATTAACAGATCAGCATGTCCAGCTCCCC
ATGGCAATGACTGCAGAGAATCTTGCTGTAAAACACAAAATAAGCAGAGAAGAATGTGAC
AAATATGCCCTGCAGTCACAGCAGAGATGGAAAGCTGCTAATGATGCTGGCTACTTTAAT
GATGAAATGGCACCAATTGAAGTGAAGACAAAGAAAGGAAAACAGACAATGCAGGTAGAC
GAGCATGCTCGGCCCCAAACCACCCTGGAACAGTTACAGAAACTTCCTCCAGTATTCAAG
AAAGATGGAACTGTTACTGCAGGGAATGCATCGGGTGTAGCTGATGGTGCTGGAGCTGTT
ATCATAGCTAGTGAAGATGCTGTTAAGAAACATAACTTCACACCACTGGCAAGAATTGTG
GGCTACTTTGTATCTGGATGTGATCCCTCTATCATGGGTATTGGTCCTGTCCCTGCTATC
AGTGGGGCACTGAAGAAAGCAGGACTGAGTCTTAAGGACATGGATTTGGTAGAGGTGAAT
GAAGCTTTTGCTCCCCAGTACTTGGCTGTTGAGAGGAGTTTGGATCTTGACATAAGTAAA
ACCAATGTGAATGGAGGAGCCATTGCTTTGGGTCACCCACTGGGAGGATCTGGATCAAGA
ATTACTGCACACCTGGTTCACGAATTAAGGCGTCGAGGTGGAAAATATGCCGTTGGATCA
GCTTGCATTGGAGGTGGCCAAGGTATTGCTGTCATCATTCAGAGCACAGCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 397 |
| Molecular Weight
| 41923.82 |
| Theoretical pI
| 8.09 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>3-ketoacyl-CoA thiolase, mitochondrial
MALLRGVFVVAAKRTPFGAYGGLLKDFTATDLSEFAAKAALSAGKVSPETVDSVIMGNVL
QSSSDAIYLARHVGLRVGIPKETPALTINRLCGSGFQSIVNGCQEICVKEAEVVLCGGTE
SMSQAPYCVRNVRFGTKLGSDIKLEDSLWVSLTDQHVQLPMAMTAENLAVKHKISREECD
KYALQSQQRWKAANDAGYFNDEMAPIEVKTKKGKQTMQVDEHARPQTTLEQLQKLPPVFK
KDGTVTAGNASGVADGAGAVIIASEDAVKKHNFTPLARIVGYFVSGCDPSIMGIGPVPAI
SGALKKAGLSLKDMDLVEVNEAFAPQYLAVERSLDLDISKTNVNGGAIALGHPLGGSGSR
ITAHLVHELRRRGGKYAVGSACIGGGQGIAVIIQSTA
|
| External Links |
|---|
| GenBank ID Protein
| 12804931 |
| UniProtKB/Swiss-Prot ID
| P42765 |
| UniProtKB/Swiss-Prot Entry Name
| THIM_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC001918 |
| GeneCard ID
| ACAA2 |
| GenAtlas ID
| ACAA2 |
| HGNC ID
| HGNC:83 |
| References |
|---|
| General References
| Not Available |