Cannabis Compound Database: Showing Protein Serotonin N-acetyltransferase (CDBP00030)

Identification Biological properties Gene properties Protein properties External links References XML Show 4 compounds

Identification

HMDB Protein ID

CDBP00030

Secondary Accession Numbers

Not Available

Name

Serotonin N-acetyltransferase

Description

Not Available

Synonyms

AA-NAT
Aralkylamine N-acetyltransferase
Serotonin acetylase

Gene Name

AANAT

Protein Type

Enzyme

Biological Properties

General Function

Involved in N-acetyltransferase activity

Specific Function

Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.

GO Classification

Biological Process
cellular response to cAMP
response to insulin stimulus
response to corticosterone stimulus
response to cytokine stimulus
circadian rhythm
response to copper ion
small molecule metabolic process
response to zinc ion
indolalkylamine biosynthetic process
melatonin biosynthetic process
response to prostaglandin E stimulus
response to light stimulus
response to calcium ion
N-terminal protein amino acid acetylation
Cellular Component
cytosol
perinuclear region of cytoplasm
Function
catalytic activity
transferase activity
transferase activity, transferring acyl groups
transferase activity, transferring acyl groups other than amino-acyl groups
acyltransferase activity
acetyltransferase activity
n-acetyltransferase activity
Molecular Function
arylamine N-acetyltransferase activity
aralkylamine N-acetyltransferase activity
Process
metabolic process

Cellular Location

Cytoplasm

Pathways

Name	SMPDB/Pathwhiz	KEGG
melatonin biosynthesis	Not Available	Not Available
Tryptophan Metabolism

Gene Properties

Chromosome Location

Locus

17q25

SNPs

AANAT

Gene Sequence

>624 bp
ATGTCCACGCAGAGCACCCACCCCCTGAAACCTGAGGCCCCACGTCTGCCACCTGGGATC
CCCGAGTCCCCGAGCTGTCAGCGGCGCCACACACTCCCTGCCAGTGAGTTTCGCTGCCTC
ACCCCGGAGGACGCTGTCAGCGCCTTTGAGATCGAGCGTGAAGCCTTCATCTCCGTCTTG
GGCGTCTGCCCCCTGTACCTGGATGAGATCCGGCACTTCCTGACCCTATGTCCAGAGCTG
TCCCTGGGCTGGTTCGAGGAGGGCTGCCTTGTGGCCTTCATCATCGGCTCGCTCTGGGAC
AAGGAGAGACTCATGCAGGAGTCACTGACGCTGCACAGGTCTGGGGGCCACATAGCCCAC
CTGCATGTGCTGGCCGTGCACCGCGCCTTCCGGCAGCAGGGCAGGGGCCCCATCCTGCTG
TGGCGCTACCTGCACCACCTGGGCAGCCAGCCGGCCGTGCGCCGGGCCGCGCTCATGTGC
GAGGACGCGCTGGTACCCTTCTATGAGAGGTTCAGCTTCCACGCCGTGGGCCCCTGCGCC
ATCACCGTGGGCTCCCTCACCTTCATGGAGCTCCACTGCTCCCTGCGGGGCCACCCCTTC
CTGCGCAGGAACAGCGGCTGCTGA

Protein Properties

Number of Residues

207

Molecular Weight

23343.8

Theoretical pI

7.526

Pfam Domain Function

Acetyltransf_1 (PF00583 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Serotonin N-acetyltransferase
MSTQSTHPLKPEAPRLPPGIPESPSCQRRHTLPASEFRCLTPEDAVSAFEIEREAFISVL
GVCPLYLDEIRHFLTLCPELSLGWFEEGCLVAFIIGSLWDKERLMQESLTLHRSGGHIAH
LHVLAVHRAFRQQGRGPILLWRYLHHLGSQPAVRRAALMCEDALVPFYERFSFHAVGPCA
ITVGSLTFMELHCSLRGHPFLRRNSGC

External Links

GenBank ID Protein

Not Available

UniProtKB/Swiss-Prot ID

Q16613

UniProtKB/Swiss-Prot Entry Name

SNAT_HUMAN

PDB IDs

Not Available

GenBank Gene ID

U40347

GeneCard ID