| Identification |
|---|
| HMDB Protein ID
| CDBP00029 |
| Secondary Accession Numbers
| Not Available |
| Name
| Diamine acetyltransferase 1 |
| Description
| Not Available |
| Synonyms
|
- Polyamine N-acetyltransferase 1
- Putrescine acetyltransferase
- SSAT
- SSAT-1
- Spermidine/spermine N(1)-acetyltransferase 1
|
| Gene Name
| SAT1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in N-acetyltransferase activity |
| Specific Function
| Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine.
|
| GO Classification
|
| Biological Process |
| small molecule metabolic process |
| regulation of cell proliferation |
| polyamine biosynthetic process |
| angiogenesis |
| putrescine catabolic process |
| Cellular Component |
| cytosol |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring acyl groups |
| transferase activity, transferring acyl groups other than amino-acyl groups |
| acyltransferase activity |
| acetyltransferase activity |
| n-acetyltransferase activity |
| Molecular Function |
| diamine N-acetyltransferase activity |
| spermidine binding |
| Process |
| metabolic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | putrescine degradation | Not Available | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| X |
| Locus
| Xp22.1 |
| SNPs
| SAT1 |
| Gene Sequence
|
>516 bp
ATGGCTAAATTCGTGATCCGCCCAGCCACTGCCGCCGACTGCAGTGACATACTGCGGCTG
ATCAAGGAGCTGGCTAAATATGAATACATGGAAGAACAAGTAATCTTAACTGAAAAAGAT
CTGCTAGAAGATGGTTTTGGAGAGCACCCCTTTTACCACTGCCTGGTTGCAGAAGTGCCG
AAAGAGCACTGGACTCCGGAAGGACACAGCATTGTTGGTTTTGCCATGTACTATTTTACC
TATGACCCGTGGATTGGCAAGTTATTGTATCTTGAGGACTTCTTCGTGATGAGTGATTAT
AGAGGCTTTGGCATAGGATCAGAAATTCTGAAGAATCTAAGCCAGGTTGCAATGAGGTGT
CGCTGCAGCAGCATGCACTTCTTGGTAGCAGAATGGAATGAACCATCCATCAACTTCTAT
AAAAGAAGAGGTGCTTCTGATCTGTCCAGTGAAGAGGGTTGGAGACTGTTCAAGATCGAC
AAGGAGTACTTGCTAAAAATGGCAACAGAGGAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 171 |
| Molecular Weight
| 20023.8 |
| Theoretical pI
| 5.152 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Diamine acetyltransferase 1
MAKFVIRPATAADCSDILRLIKELAKYEYMEEQVILTEKDLLEDGFGEHPFYHCLVAEVP
KEHWTPEGHSIVGFAMYYFTYDPWIGKLLYLEDFFVMSDYRGFGIGSEILKNLSQVAMRC
RCSSMHFLVAEWNEPSINFYKRRGASDLSSEEGWRLFKIDKEYLLKMATEE
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P21673 |
| UniProtKB/Swiss-Prot Entry Name
| SAT1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| M77693 |
| GeneCard ID
| SAT1 |
| GenAtlas ID
| SAT1 |
| HGNC ID
| HGNC:10540 |
| References |
|---|
| General References
| Not Available |