| Identification |
|---|
| HMDB Protein ID
| CDBP00020 |
| Secondary Accession Numbers
| Not Available |
| Name
| Arylamine N-acetyltransferase 1 |
| Description
| Not Available |
| Synonyms
|
- Arylamide acetylase 1
- MNAT
- Monomorphic arylamine N-acetyltransferase
- N-acetyltransferase type 1
- NAT-1
|
| Gene Name
| NAT1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in acetyltransferase activity |
| Specific Function
| Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.
|
| GO Classification
|
| Biological Process |
| small molecule metabolic process |
| xenobiotic metabolic process |
| Cellular Component |
| cytosol |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring acyl groups |
| transferase activity, transferring acyl groups other than amino-acyl groups |
| acyltransferase activity |
| acetyltransferase activity |
| Molecular Function |
| arylamine N-acetyltransferase activity |
| Process |
| metabolic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Drug metabolism - other enzymes | Not Available |  | | Chemical carcinogenesis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| 8p22 |
| SNPs
| NAT1 |
| Gene Sequence
|
>873 bp
ATGGACATTGAAGCATATCTTGAAAGAATTGGCTATAAGAAGTCTAGGAACAAATTGGAC
TTGGAAACATTAACTGACATTCTTCAACACCAGATCCGAGCTGTTCCCTTTGAGAACCTT
AACATCCATTGTGGGGATGCCATGGACTTAGGCTTAGAGGCCATTTTTGATCAAGTTGTG
AGAAGAAATTGGGGTGGATGGTGTCTCCAGGTCAATCATCTTCTGTACTGGGCTCTGACC
ACTATTGGTTTTGAGACCACGATGTTGGGAGGGTATGTTTACAGCACTCCAGCCAAAAAA
TACAGCACTGGCATGATTCACCTTCTCCTGCAGGTGACCATTGATGGCAGGAACTACATT
GTCGATGCTGGGTTTGGACGCTCATACCAGATGTGGCAGCCTCTGGAGTTAATTTCTGGG
AAGGATCAGCCTCAGGTGCCTTGTGTCTTCCGTTTGACGGAAGAGAATGGATTCTGGTAT
CTAGACCAAATCAGAAGGGAACAGTACATTCCAAATGAAGAATTTCTTCATTCTGATCTC
CTAGAAGACAGCAAATACCGAAAAATCTACTCCTTTACTCTTAAGCCTCGAACAATTGAA
GATTTTGAGTCTATGAATACATACCTGCAGACATCTCCATCATCTGTGTTTACTAGTAAA
TCATTTTGTTCCTTGCAGACCCCAGATGGGGTTCACTGTTTGGTGGGCTTCACCCTCACC
CATAGGAGATTCAATTATAAGGACAATACAGATCTAATAGAGTTCAAGACTCTGAGTGAG
GAAGAAATAGAAAAAGTGCTGAAAAATATATTTAATATTTCCTTGCAGAGAAAGCTTGTG
CCCAAACATGGTGATAGATTTTTTACTATTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 290 |
| Molecular Weight
| 33898.445 |
| Theoretical pI
| 6.537 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Arylamine N-acetyltransferase 1
MDIEAYLERIGYKKSRNKLDLETLTDILQHQIRAVPFENLNIHCGDAMDLGLEAIFDQVV
RRNRGGWCLQVNHLLYWALTTIGFETTMLGGYVYSTPAKKYSTGMIHLLLQVTIDGRNYI
VDAGFGRSYQMWQPLELISGKDQPQVPCVFRLTEENGFWYLDQIRREQYIPNEEFLHSDL
LEDSKYRKIYSFTLKPRTIEDFESMNTYLQTSPSSVFTSKSFCSLQTPDGVHCLVGFTLT
HRRFNYKDNTDLIEFKTLSEEEIEKVLKNIFNISLQRKLVPKHGDRFFTI
|
| External Links |
|---|
| GenBank ID Protein
| 2258431 |
| UniProtKB/Swiss-Prot ID
| P18440 |
| UniProtKB/Swiss-Prot Entry Name
| ARY1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF008204 |
| GeneCard ID
| NAT1 |
| GenAtlas ID
| NAT1 |
| HGNC ID
| HGNC:7645 |
| References |
|---|
| General References
| Not Available |