| Identification |
|---|
| HMDB Protein ID
| CDBP00003 |
| Secondary Accession Numbers
| Not Available |
| Name
| UMP-CMP kinase |
| Description
| Not Available |
| Synonyms
|
- Cytidine monophosphate kinase
- Cytidylate kinase
- Deoxycytidylate kinase
- UMP/CMP kinase
- UMP/CMPK
- Uridine monophosphate kinase
- Uridine monophosphate/cytidine monophosphate kinase
|
| Gene Name
| CMPK1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Catalyzes specific phosphoryl transfer from ATP to UMP and CMP.
|
| GO Classification
|
| Biological Process |
| nucleobase-containing small molecule interconversion |
| Cellular Component |
| cytosol |
| nucleus |
| Function |
| nucleotide kinase activity |
| phosphotransferase activity, phosphate group as acceptor |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| nucleobase, nucleoside, nucleotide kinase activity |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| atp binding |
| binding |
| catalytic activity |
| Molecular Function |
| ATP binding |
| cytidylate kinase activity |
| phosphotransferase activity, phosphate group as acceptor |
| uridine kinase activity |
| Process |
| nitrogen compound metabolic process |
| cellular nitrogen compound metabolic process |
| nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
| metabolic process |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Lactose Synthesis |    | Not Available | | Congenital disorder of glycosylation CDG-IId |    | Not Available | | GLUT-1 deficiency syndrome |    | Not Available | | Gemcitabine Action Pathway |    | Not Available | | Gemcitabine Metabolism Pathway |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1p32 |
| SNPs
| CMPK1 |
| Gene Sequence
|
>591 bp
ATGAAGCCGCTGGTCGTGTTCGTCCTCGGCGGCCCCGGCGCCGGCAAGGGGACCCAGTGC
GCCCGCATCGTCGAGAAATATGGCTACACACACCTTTCTGCAGGAGAGCTGCTTCGTGAT
GAAAGGAAGAACCCAGATTCACAGTATGGTGAACTTATTGAAAAGTACATTAAAGAAGGA
AAGATTGTACCAGTTGAGATAACCATCAGTTTATTAAAGAGGGAAATGGATCAGACAATG
GCTGCCAATGCTCAGAAGAATAAATTCTTGATTGATGGGTTTCCAAGAAATCAAGACAAC
CTTCAAGGATGGAACAAGACCATGGATGGGAAGGCAGATGTATCTTTCGTTCTCTTTTTT
GACTGTAATAATGAGATTTGTATTGAACGATGTCTTGAGAGGGGAAAGAGTAGTGGTAGG
AGTGATGACAACAGAGAGAGCTTGGAAAAGAGAATTCAGACCTACCTTCAGTCAACAAAG
CCAATTATTGACTTATATGAAGAAATGGGGAAAGTCAAGAAAATAGATGCTTCTAAATCT
GTTGATGAAGTTTTTGATGAAGTTGTGCAGATTTTTGACAAGGAAGGCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 196 |
| Molecular Weight
| 20180.12 |
| Theoretical pI
| 7.631 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>UMP-CMP kinase
MKPLVVFVLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNPDSQYGELIEKYIKEG
KIVPVEITISLLKREMDQTMAANAQKNKFLIDGFPRNQDNLQGWNKTMDGKADVSFVLFF
DCNNEICIERCLERGKSSGRSDDNRESLEKRIQTYLQSTKPIIDLYEEMGKVKKIDASKS
VDEVFDEVVQIFDKEG
|
| External Links |
|---|
| GenBank ID Protein
| 33150592 |
| UniProtKB/Swiss-Prot ID
| P30085 |
| UniProtKB/Swiss-Prot Entry Name
| KCY_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF087865 |
| GeneCard ID
| CMPK1 |
| GenAtlas ID
| CMPK1 |
| HGNC ID
| HGNC:18170 |
| References |
|---|
| General References
| Not Available |