Cannabis Compound Database: Showing Compound Card for L-Tryptophan (CDB004871)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (9)transporters (2) Show 16 proteins XML

Record Information

Version

1.0

Created at

2020-04-17 18:45:24 UTC

Updated at

2020-12-07 19:11:09 UTC

CannabisDB ID

CDB004871

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

L-Tryptophan

Description

L-Tryptophan, also known as Trp or W, belongs to the class of organic compounds known as indolyl carboxylic acids and derivatives. Indolyl carboxylic acids and derivatives are compounds containing a carboxylic acid chain (of at least 2 carbon atoms) linked to an indole ring. L-Tryptophan is a very strong basic compound (based on its pKa). L-Tryptophan exists in all living species, ranging from bacteria to humans. Within humans, L-tryptophan participates in a number of enzymatic reactions. In particular, L-tryptophan can be converted into n'-formylkynurenine through the action of the enzyme tryptophan 2,3-dioxygenase. In addition, L-tryptophan and tetrahydrobiopterin can be converted into 5-hydroxy-L-tryptophan and 4a-hydroxytetrahydrobiopterin through its interaction with the enzyme tryptophan 5-hydroxylase 1. The L-enantiomer of tryptophan. In humans, L-tryptophan is involved in tryptophan metabolism. Outside of the human body, L-Tryptophan is found, on average, in the highest concentration within a few different foods, such as caseins, steller sea lions, and evening primroses and in a lower concentration in thunnus, kefirs, and garden onions. L-Tryptophan has also been detected, but not quantified in, several different foods, such as thistles, gelatins, garden onion (var.), alpine sweetvetchs, and remoulades. This could make L-tryptophan a potential biomarker for the consumption of these foods. L-Tryptophan is a potentially toxic compound. L-Tryptophan is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
(2S)-2-Amino-3-(1H-indol-3-yl)propanoic acid	ChEBI
(S)-alpha-Amino-1H-indole-3-propanoic acid	ChEBI
(S)-alpha-Amino-beta-(3-indolyl)-propionic acid	ChEBI
(S)-Tryptophan	ChEBI
L-(-)-Tryptophan	ChEBI
L-beta-3-Indolylalanine	ChEBI
Trp	ChEBI
Tryptophan	ChEBI
W	ChEBI
(2S)-2-Amino-3-(1H-indol-3-yl)propanoate	Generator
(S)-a-Amino-1H-indole-3-propanoate	Generator
(S)-a-Amino-1H-indole-3-propanoic acid	Generator
(S)-alpha-Amino-1H-indole-3-propanoate	Generator
(S)-Α-amino-1H-indole-3-propanoate	Generator
(S)-Α-amino-1H-indole-3-propanoic acid	Generator
(S)-a-Amino-b-(3-indolyl)-propionate	Generator
(S)-a-Amino-b-(3-indolyl)-propionic acid	Generator
(S)-alpha-Amino-beta-(3-indolyl)-propionate	Generator
(S)-Α-amino-β-(3-indolyl)-propionate	Generator
(S)-Α-amino-β-(3-indolyl)-propionic acid	Generator
L-b-3-Indolylalanine	Generator
L-Β-3-indolylalanine	Generator
(-)-Tryptophan	HMDB
(L)-Tryptophan	HMDB
(S)-1H-Indole-3-alanine	HMDB
(S)-2-Amino-3-(3-indolyl)propionic acid	HMDB
(S)-a-Amino-b-indolepropionate	HMDB
(S)-a-Amino-b-indolepropionic acid	HMDB
(S)-a-Aminoindole-3-propionate	HMDB
(S)-a-Aminoindole-3-propionic acid	HMDB
(S)-alpha-Amino-beta-indolepropionate	HMDB
(S)-alpha-Amino-beta-indolepropionic acid	HMDB
(S)-alpha-Aminoindole-3-propionate	HMDB
(S)-alpha-Aminoindole-3-propionic acid	HMDB
1-beta-3-Indolylalanine	HMDB
1beta-3-Indolylalanine	HMDB
1H-Indole-3-alanine	HMDB
2-Amino-3-indolylpropanoate	HMDB
2-Amino-3-indolylpropanoic acid	HMDB
3-(1H-indol-3-yl)-L-Alanine	HMDB
3-indol-3-Ylalanine	HMDB
Alpha'-amino-3-indolepropionic acid	HMDB
alpha-Aminoindole-3-propionic acid	HMDB
Ardeytropin	HMDB
H-TRP-OH	HMDB
Indole-3-alanine	HMDB
Kalma	HMDB
L-alpha-Amino-3-indolepropionic acid	HMDB
L-alpha-Aminoindole-3-propionic acid	HMDB
L-Tryptofan	HMDB
L-Tryptophane	HMDB
Lopac-T-0254	HMDB
Lyphan	HMDB
Optimax	HMDB
Pacitron	HMDB
Sedanoct	HMDB
Triptofano	HMDB
Trofan	HMDB
Tryptacin	HMDB
Tryptan	HMDB
Tryptophane	HMDB
Tryptophanum	HMDB
Ardeydorm	HMDB
L Tryptophan	HMDB
L-Tryptophan-ratiopharm	HMDB
Merck brand OF tryptophan	HMDB
Niddapharm brand OF tryptophan	HMDB
ICN brand OF tryptophan	HMDB
Levotryptophan	HMDB
PMS Tryptophan	HMDB
PMS-Tryptophan	HMDB
Ratiopharm brand OF tryptophan	HMDB
Esparma brand OF tryptophan	HMDB
Ratio-tryptophan	HMDB
L Tryptophan ratiopharm	HMDB
Naturruhe	HMDB
Tryptophan metabolism alterations	HMDB
Ardeypharm brand OF tryptophan	HMDB
Kalma brand OF tryptophan	HMDB
Pharmascience brand OF tryptophan	HMDB
Upsher-smith brand OF tryptophan	HMDB
Ratio tryptophan	HMDB

Chemical Formula

C₁₁H₁₂N₂O₂

Average Molecular Weight

204.23

Monoisotopic Molecular Weight

204.0899

IUPAC Name

(2S)-2-amino-3-(1H-indol-3-yl)propanoic acid

Traditional Name

L-tryptophan

CAS Registry Number

73-22-3

SMILES

N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

InChI Identifier

InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1

InChI Key

QIVBCDIJIAJPQS-VIFPVBQESA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as indolyl carboxylic acids and derivatives. Indolyl carboxylic acids and derivatives are compounds containing a carboxylic acid chain (of at least 2 carbon atoms) linked to an indole ring.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Indoles and derivatives

Sub Class

Indolyl carboxylic acids and derivatives

Direct Parent

Indolyl carboxylic acids and derivatives

Alternative Parents

Substituents

Indolyl carboxylic acid derivative
Alpha-amino acid
Alpha-amino acid or derivatives
L-alpha-amino acid
3-alkylindole
Indole
Aralkylamine
Benzenoid
Substituted pyrrole
Heteroaromatic compound
Pyrrole
Amino acid or derivatives
Amino acid
Carboxylic acid derivative
Carboxylic acid
Monocarboxylic acid or derivatives
Azacycle
Amine
Primary aliphatic amine
Hydrocarbon derivative
Organic oxide
Organic oxygen compound
Organic nitrogen compound
Carbonyl group
Organonitrogen compound
Organooxygen compound
Primary amine
Organopnictogen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

proteinogenic amino acid (CHEBI:16828 )
L-alpha-amino acid (CHEBI:16828 )
tryptophan (CHEBI:16828 )
erythrose 4-phosphate/phosphoenolpyruvate family amino acid (CHEBI:16828 )
Common amino acids (C00078 )

Ontology

Ingestion

Source:

Food

Synthetic:

Personal care product

Biological:

Animal

Plant:

Biological location:

Role

Indirect biological role:

Industrial application:

Food and nutrition:

Nutritional supplement

Pharmaceutical industry:

Biological role:

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	230 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	13.4 mg/mL at 25 °C	YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP	-1.06	HANSCH,C ET AL. (1995)

Predicted Properties

Property	Value	Source
logP	-1.1	ALOGPS
logP	-1.1	ChemAxon
logS	-2.2	ALOGPS
pKa (Strongest Acidic)	2.54	ChemAxon
pKa (Strongest Basic)	9.4	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	79.11 Å²	ChemAxon
Rotatable Bond Count	3	ChemAxon
Refractivity	56.2 m³·mol⁻¹	ChemAxon
Polarizability	21.05 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
GC-MS	L-Tryptophan, 3 TMS, GC-MS Spectrum	splash10-0udi-0190000000-feaec8547634dddcad8c	Spectrum
GC-MS	L-Tryptophan, 3 TMS, GC-MS Spectrum	splash10-0udi-0390000000-45a6c4fd79081597d44a	Spectrum
GC-MS	L-Tryptophan, non-derivatized, GC-MS Spectrum	splash10-0udi-0290000000-34f7274f31a4cb321a0b	Spectrum
GC-MS	L-Tryptophan, 3 TMS, GC-MS Spectrum	splash10-0fk9-9270000000-9761607cbe821f87f172	Spectrum
GC-MS	L-Tryptophan, 1 TMS, GC-MS Spectrum	splash10-001i-0900000000-3faeed7ad32e1755c03c	Spectrum
GC-MS	L-Tryptophan, 3 TMS, GC-MS Spectrum	splash10-0udi-0290000000-9c57a732e337fade3cb6	Spectrum
GC-MS	L-Tryptophan, non-derivatized, GC-MS Spectrum	splash10-001i-0900000000-d054a214c1717940989f	Spectrum
GC-MS	L-Tryptophan, non-derivatized, GC-MS Spectrum	splash10-0udi-0290000000-9860799c854e5c9ac1c7	Spectrum
GC-MS	L-Tryptophan, non-derivatized, GC-MS Spectrum	splash10-0udi-0190000000-feaec8547634dddcad8c	Spectrum
GC-MS	L-Tryptophan, non-derivatized, GC-MS Spectrum	splash10-0udi-0390000000-45a6c4fd79081597d44a	Spectrum
GC-MS	L-Tryptophan, non-derivatized, GC-MS Spectrum	splash10-0udi-0290000000-34f7274f31a4cb321a0b	Spectrum
GC-MS	L-Tryptophan, non-derivatized, GC-MS Spectrum	splash10-0udi-3729000000-86129db57aaf1a245f93	Spectrum
GC-MS	L-Tryptophan, non-derivatized, GC-MS Spectrum	splash10-0fk9-9270000000-9761607cbe821f87f172	Spectrum
GC-MS	L-Tryptophan, non-derivatized, GC-MS Spectrum	splash10-001i-0900000000-3faeed7ad32e1755c03c	Spectrum
GC-MS	L-Tryptophan, non-derivatized, GC-MS Spectrum	splash10-0udi-0290000000-9c57a732e337fade3cb6	Spectrum
Predicted GC-MS	L-Tryptophan, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0560-4900000000-fa932bc4cffed0ca66b7	Spectrum
Predicted GC-MS	L-Tryptophan, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-00e9-9560000000-6829a8b2a2096883999f	Spectrum
Predicted GC-MS	L-Tryptophan, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Tryptophan, TMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Tryptophan, TMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Tryptophan, TBDMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Tryptophan, TBDMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Tryptophan, TBDMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0udi-0290602010-c09c931538bff74ac400	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0a4i-0900000000-0fed327c2a56f556e04c	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0udi-0090000000-98ec1c2c012e58eab924	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-00di-0090000000-fc77784da5d9b288d751	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0udi-0290601010-d6f94902c0cf639cb7bc	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0a4i-0900000000-27633a4f7ecfac45c730	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0udi-0090000000-ee6cb8392b2e8d644bc1	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-004i-0090000000-d81c86eceee1c9824b02	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative	splash10-0udi-0190000000-0e8b883dc8ab06c89d77	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative	splash10-0uxu-2940000000-cb35b9680612e19d8b3a	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative	splash10-014i-2900000000-7cc592351cc616b1d75f	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative	splash10-014i-1900000000-987615a0add5eb2c3169	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negative	splash10-014i-1900000000-f150d9d1e19c72d337a8	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negative	splash10-0uxr-2960000000-f4c878f3abb1609bb5c5	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , negative	splash10-0udi-0090000000-c73c9b49139319c80b18	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , negative	splash10-0gb9-0930000000-da94834297fcc5b3d3c5	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , negative	splash10-014i-0900000000-94061fd1f6b08445cdf3	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , negative	splash10-014i-0900000000-e78172f4f27df232466e	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , negative	splash10-014i-0900000000-93406e2cdb79770abc7d	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-0udi-0190000000-0e8b883dc8ab06c89d77	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-0uxu-2940000000-cb35b9680612e19d8b3a	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-014i-2900000000-5187dac98dbd6834d6ba	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-014i-1900000000-987615a0add5eb2c3169	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-014i-1900000000-174bb4d4390c75ae9a09	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT , negative	splash10-0a4i-0900000000-0fed327c2a56f556e04c	2017-09-14	View Spectrum

NMR

Type	Description	View
1D NMR	¹³C NMR Spectrum (1D, 125 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, experimental)	Spectrum
2D NMR	[¹H, ¹H]-TOCSY. Unexported temporarily by An Chi on Oct 15, 2021 until json or nmrML file is generated. 2D NMR Spectrum (experimental)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Tryptophan Metabolism
Transcription/Translation	Not Available	Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Aromatic-L-amino-acid decarboxylase	DDC	7p12.2	P20711	details
Indoleamine 2,3-dioxygenase 1	IDO1	8p12-p11	P14902	details
Tryptophan 5-hydroxylase 1	TPH1	11p15.3-p14	P17752	details
Tryptophan 5-hydroxylase 2	TPH2	12q21.1	Q8IWU9	details
Tryptophan--tRNA ligase, cytoplasmic	WARS	14q32.31	P23381	details
Tryptophan--tRNA ligase, mitochondrial	WARS2	1p12	Q9UGM6	details
Tryptophan 2,3-dioxygenase	TDO2	4q31-q32	P48775	details
Indoleamine 2,3-dioxygenase 2	IDO2	8p11.21	Q6ZQW0	details
L-amino-acid oxidase	IL4I1	19q13.3-q13.4	Q96RQ9	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Monocarboxylate transporter 8	SLC16A2		P36021	details
Monocarboxylate transporter 10	SLC16A10	6q21-q22	Q8TF71	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Indoleamine 2,3-dioxygenase 1	IDO1	8p12-p11	P14902	details
Tryptophan 5-hydroxylase 1	TPH1	11p15.3-p14	P17752	details
Tryptophan 5-hydroxylase 2	TPH2	12q21.1	Q8IWU9	details
Tryptophan 2,3-dioxygenase	TDO2	4q31-q32	P48775	details
Indoleamine 2,3-dioxygenase 2	IDO2	8p11.21	Q6ZQW0	details

Receptors

Not Available

Transcriptional Factors

Not Available

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0000929

DrugBank ID

DB00150

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

METLIN ID

PubChem Compound

PDB ID

Not Available

ChEBI ID

16828

References

General References

Not Available

Only showing the first 10 proteins. There are 16 proteins in total.

Show All

Enzymes

Enzyme Details

1. Aromatic-L-amino-acid decarboxylase

General function:: Involved in carboxy-lyase activity
Specific function:: Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
Gene Name:: DDC
Uniprot ID:: P20711
Molecular weight:: 53893.755

Enzyme Details

2. Indoleamine 2,3-dioxygenase 1

General function:: Involved in heme binding
Specific function:: Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen.
Gene Name:: IDO1
Uniprot ID:: P14902
Molecular weight:: 45325.89

Enzyme Details

3. Tryptophan 5-hydroxylase 1

General function:: Involved in amino acid binding
Specific function:: Not Available
Gene Name:: TPH1
Uniprot ID:: P17752
Molecular weight:: 50984.725

Enzyme Details

4. Tryptophan 5-hydroxylase 2

General function:: Involved in amino acid binding
Specific function:: Not Available
Gene Name:: TPH2
Uniprot ID:: Q8IWU9
Molecular weight:: 56056.295

Enzyme Details

5. Tryptophan--tRNA ligase, cytoplasmic

General function:: Involved in nucleotide binding
Specific function:: Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression.
Gene Name:: WARS
Uniprot ID:: P23381
Molecular weight:: 53164.91

Enzyme Details

6. Tryptophan--tRNA ligase, mitochondrial

General function:: Involved in nucleotide binding
Specific function:: Not Available
Gene Name:: WARS2
Uniprot ID:: Q9UGM6
Molecular weight:: 40146.265

Enzyme Details

7. Tryptophan 2,3-dioxygenase

General function:: Involved in tryptophan 2,3-dioxygenase activity
Specific function:: Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity).
Gene Name:: TDO2
Uniprot ID:: P48775
Molecular weight:: 47871.215

Enzyme Details

8. Indoleamine 2,3-dioxygenase 2

General function:: Involved in heme binding
Specific function:: Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism.
Gene Name:: IDO2
Uniprot ID:: Q6ZQW0
Molecular weight:: 47074.745

Enzyme Details

9. L-amino-acid oxidase

General function:: Involved in oxidoreductase activity
Specific function:: Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity).
Gene Name:: IL4I1
Uniprot ID:: Q96RQ9
Molecular weight:: 65327.26

Transporters

Enzyme Details

1. Monocarboxylate transporter 8

General function:: Involved in transmembrane transport
Specific function:: Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr
Gene Name:: SLC16A2
Uniprot ID:: P36021
Molecular weight:: 59510.9

Enzyme Details

2. Monocarboxylate transporter 10

General function:: Involved in transmembrane transport
Specific function:: Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells
Gene Name:: SLC16A10
Uniprot ID:: Q8TF71
Molecular weight:: 55492.1

Only showing the first 10 proteins. There are 16 proteins in total.

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Showing Compound Card for L-Tryptophan (CDB004871)

Structure for CDB004871 (L-Tryptophan)

Enzymes

Transporters