Showing Compound Card for PG(18:1(9Z)/18:1(9Z)) (CDB001179)

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Record Information
Version1.0
Created at2020-03-30 18:09:02 UTC
Updated at2020-12-07 19:07:59 UTC
CannabisDB IDCDB001179
Secondary Accession NumbersNot Available
Cannabis Compound Identification
Common NamePG(18:1(9Z)/18:1(9Z))
DescriptionPG(18:1(9Z)/18:1(9Z)) is a phosphatidylglycerol. Phosphatidylglycerols consist of a glycerol 3-phosphate backbone esterified to either saturated or unsaturated fatty acids on carbons 1 and 2. As is the case with diacylglycerols, phosphatidylglycerols can have many different combinations of fatty acids of varying lengths and saturation attached to the C-1 and C-2 positions. PG(18:1(9Z)/18:1(9Z)), in particular, consists of two 9Z-octadecenoyl chains at positions C-1 and C-2. In E. coli glycerophospholipid metabolism, phosphatidylglycerol is formed from phosphatidic acid (1,2-diacyl-sn-glycerol 3-phosphate) by a sequence of enzymatic reactions that proceeds via two intermediates, cytidine diphosphate diacylglycerol (CDP-diacylglycerol) and phosphatidylglycerophosphate (PGP, a phosphorylated phosphatidylglycerol). Phosphatidylglycerols, along with CDP-diacylglycerol, also serve as precursor molecules for the synthesis of cardiolipin, a phospholipid found in membranes. This compound is expected to be in Cannabis as all living plants are known to produce and metabolize it.
Structure
Thumb
MOLSDFPDBSMILESInChI
Synonyms
ValueSource
1,2-Di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)ChEBI
1,2-Di-[(9Z)-octadecenoyl]-sn-glycero-3-phospho-(1'-sn-glycerol)ChEBI
1,2-Dioleoyl-sn-3-phosphatidylglycerolChEBI
1,2-Dioleoyl-sn-glycero-3-phosphoglycerolChEBI
PG(18:1/18:1)ChEBI
PG(18:1OMEGA9/18:1OMEGA9)ChEBI
PG(36:2)ChEBI
Phosphatidylglycerol(18:1/18:1)ChEBI
Phosphatidylglycerol(18:1omega9/18:1omega9)ChEBI
Phosphatidylglycerol(36:2)ChEBI
1,2-Dioleoyl-sn-glycero-3-phosphoglycerol, (Z)-isomerMeSH
1,2-DioleoylphosphatidylglycerolMeSH
1,2-Dioleoyl-sn-glycero-3-phospho(1-rac-glycerol)MeSH
1,2-Dioleoyl-sn-glycero-3-phosphoglycerol, (R-(r*,s*))-(Z)-isomerMeSH
DOPGMeSH
Di-C18-1(C)-PGMeSH
1,2-dioleoyl-rac-glycero-3-phosphoglycerolLipid Annotator, HMDB
PG(18:1(9Z)/18:1(9Z))Lipid Annotator
GPG(36:2)Lipid Annotator, HMDB
GPG(18:1/18:1)Lipid Annotator, HMDB
1,2-di(9Z-octadecenoyl)-rac-glycero-3-phosphoglycerolLipid Annotator, HMDB
1,2-di(9Z-octadecenoyl)-rac-glycero-3-phospho-(1'-glycerol)Lipid Annotator, HMDB
GPG(18:1N9/18:1N9)HMDB
GPG(18:1W9/18:1W9)HMDB
PG(18:1N9/18:1N9)HMDB
PG(18:1W9/18:1W9)HMDB
Phosphatidylglycerol(18:1n9/18:1n9)HMDB
Phosphatidylglycerol(18:1W9/18:1W9)HMDB
Chemical FormulaC42H79O10P
Average Molecular Weight775.06
Monoisotopic Molecular Weight774.5411
IUPAC Name[(2R)-2,3-bis[(9Z)-octadec-9-enoyloxy]propoxy][(2S)-2,3-dihydroxypropoxy]phosphinic acid
Traditional Name(2R)-2,3-bis[(9Z)-octadec-9-enoyloxy]propoxy((2S)-2,3-dihydroxypropoxy)phosphinic acid
CAS Registry NumberNot Available
SMILES
[H][C@](O)(CO)COP(O)(=O)OC[C@@]([H])(COC(=O)CCCCCCC\C=C/CCCCCCCC)OC(=O)CCCCCCC\C=C/CCCCCCCC
InChI Identifier
InChI=1S/C42H79O10P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-41(45)49-37-40(38-51-53(47,48)50-36-39(44)35-43)52-42(46)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,39-40,43-44H,3-16,21-38H2,1-2H3,(H,47,48)/b19-17-,20-18-/t39-,40+/m0/s1
InChI KeyDSNRWDQKZIEDDB-SQYFZQSCSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as phosphatidylglycerols. These are glycerophosphoglycerols in which two fatty acids are bonded to the 1-glycerol moiety through ester linkages. As is the case with diacylglycerols, phosphatidylglycerols can have many different combinations of fatty acids of varying lengths and saturation attached to the C-1 and C-2 positions.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassGlycerophospholipids
Sub ClassGlycerophosphoglycerols
Direct ParentPhosphatidylglycerols
Alternative Parents
Substituents
  • 1,2-diacylglycerophosphoglycerol
  • Fatty acid ester
  • Dialkyl phosphate
  • Dicarboxylic acid or derivatives
  • Organic phosphoric acid derivative
  • Phosphoric acid ester
  • Alkyl phosphate
  • Fatty acyl
  • 1,2-diol
  • Carboxylic acid ester
  • Secondary alcohol
  • Carboxylic acid derivative
  • Organic oxide
  • Organooxygen compound
  • Alcohol
  • Organic oxygen compound
  • Primary alcohol
  • Carbonyl group
  • Hydrocarbon derivative
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Physiological effect

Organoleptic effect:

Disposition

Route of exposure:

Source:

Biological location:

Role

Industrial application:

Biological role:

Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
logPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP8.47ALOGPS
logP11.99ChemAxon
logS-7ALOGPS
pKa (Strongest Acidic)1.89ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area148.82 ŲChemAxon
Rotatable Bond Count42ChemAxon
Refractivity215.95 m³·mol⁻¹ChemAxon
Polarizability93.13 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityNoChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Spectra
EI-MS/GC-MS
TypeDescriptionSplash KeyView
Predicted GC-MSPG(18:1(9Z)/18:1(9Z)), TMS_1_1, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSPG(18:1(9Z)/18:1(9Z)), TMS_1_2, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSPG(18:1(9Z)/18:1(9Z)), TMS_1_3, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSPG(18:1(9Z)/18:1(9Z)), TBDMS_1_1, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSPG(18:1(9Z)/18:1(9Z)), TBDMS_1_2, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSPG(18:1(9Z)/18:1(9Z)), TBDMS_1_3, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
MS/MS
TypeDescriptionSplash KeyView
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-056u-4161713900-0edb6e993315b6b70d872015-09-15View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-05xu-8294705300-166f0e559fd290f8a6992015-09-15View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-05i9-9046322000-971789173e215398bfb52015-09-15View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-01x0-0190311400-9053237cfd3ab85807832015-09-15View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-003r-5390300000-584d168169663f386c1b2015-09-15View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-004i-9020100000-b962597174cbf3c00e0d2015-09-15View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-00di-0000000900-4be40cd8142c638661cb2021-09-22View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-00f0-0190310900-bea2c111bfc5e8ef26412021-09-22View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-00e9-0390310900-b557bf36898428bf0f082021-09-22View Spectrum
NMRNot Available
Pathways
Pathways
Protein Targets
Enzymes
Protein NameGene NameLocusUniprot IDDetails
Acyl-CoA:lysophosphatidylglycerol acyltransferase 1LPGAT11q32Q92604 details
TransportersNot Available
Metal BindingsNot Available
ReceptorsNot Available
Transcriptional FactorsNot Available
Concentrations Data
Not Available
HMDB IDHMDB0010634
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FoodDB IDFDB027784
KNApSAcK IDNot Available
Chemspider ID24768133
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound52927248
PDB IDNot Available
ChEBI ID75385
References
General ReferencesNot Available

Enzymes

Enzyme Details
1. Acyl-CoA:lysophosphatidylglycerol acyltransferase 1
General function:
Involved in acyltransferase activity
Specific function:
Lysophoshatidylglycerol (LPG) specific acyltransferase that recognizes various acyl-CoAs and LPGs as substrates but demonstrates a clear preference for long chain saturated fatty acyl-CoAs and oleoyl-CoA as acyl donors. Prefers oleoyl-LPG over palmitoyl-LPG as an acyl receptor and oleoyl-CoA over lauroyl-CoA as an acyl donor
Gene Name:
LPGAT1
Uniprot ID:
Q92604
Molecular weight:
43089.1